Computational Laboratory for the Development of New Approaches to Complex Biological Phenomena

计算生物学中心将把模拟和计算扩展到真实的生物过程，特别是在分子生物物理学、分子遗传学、发育控制和进化领域。这三个主要研究项目集中在蛋白质折叠和模拟、模拟网柄菌体发育以及核酸的杂交和折叠。将使用蒙特卡洛、随机自动机和动态规划等当前的方法。新的模拟概念将使人们更好地理解对生物系统进行定量有效预测所涉及的复杂问题。这一基础广泛的设施将推动计算生物学领域的发展，计算生物学正变得越来越有必要跟踪和理解日益复杂的数据。

AbstractDBI 9970199Onuchic, JoseComputational Laboratory for the Development of new Approaches to Complex Biological PhenomenaA computational biology center will extend modeling and computation to real biological processes especially in the area of molecular biophysics, molecular genetics, developmental control and evolution. The three primary research projects concentrate on protein folding and simulation, modeling Dictyostelium development and hybridization and folding of nucleic acids. Current methodologies of MonteCarlo, stochastic automata and dynamic programming will be used. New simulation concepts will lead to a better understanding of the complicated issues involved in making quantitatively valid predictions for biological systems. This broadly based facility will advance the field of computational biology, which is becoming increasingly necessary for biologists to keep track of and make sense of data of ever increasing complexity.