POWRE: Signal Processing of Spontaneous Arrhythmias Acquired Chronically in an Adriamycin Model of Heart Failure

9973513 Schuckers在美国有100万到200万成年人受到心力衰竭的影响，每年有20万人死亡。 这些死亡中有30-50%是突然的，并归因于心脏电异常。 心电学是研究心脏电特性的学科，在预测和预防心脏性猝死方面起着重要作用。 虽然已经进行了大量的研究，试图预测心脏性猝死，没有长期的研究跟踪心电图从正常到患病状态的进展。 此外，几乎没有人在自发事件发生前几周、几天和几小时内分析心电图（ECG），以建立心源性猝死的短期电生理预测因子。 如果可以预测猝死事件，可以尝试长期和短期干预措施来预防该事件。 本提案的总体目标是开发和使用阿霉素兔心力衰竭模型，以研究从正常到猝死事件的心电图进展。动物将配备长期植入式ECG系统。将通过射频遥测在动物的整个生命周期内连续记录ECG。 将通过计算机计算经典ECG特征以及创新特征，并在动物的整个生命周期内进行监测，特别注意事件发生前的变化。这项工作的主要目标是开发一种短期预测方案，该方案可以预测即将发生的事件，以便在临床环境中进行预防/干预，如电疗。

9973513SchuckersOne to two million adults are affected in the United States by heart failure with 200,000 deaths annually. 30-50% of these deaths are sudden and have been attributed to cardiac electrical abnormalities. Electrocardiology, the study of electrical characteristics of the heart, plays a major role in prediction and prevention of sudden cardiac death. Although much research has been performed to attempt to predict sudden cardiac death, no long-term studies have tracked the electrocardiographic progression from normal to diseased state. Furthermore, little work has been done to analyze the electrocardiogram (ECG) in the weeks, days, and hours before a spontaneous event in order to establish a short-term electrophysiologic predictor of sudden cardiac death. If a sudden death episode could be predicted, long- and short-term interventions could be attempted to prevent the event. The overall goal of this proposal is to develop and use an adriamycin rabbit model of heart failure to study the electrocardiographic progression from normal to a sudden death event. Animals will be outfitted with a long-term implanted ECG system. ECGs will be recorded continuously for the lifetime of the animal through radiofrequency-telemetry. Classical ECG features as well as innovative features will be calculated by computer and monitored over the lifetime of the animal where particular attention will be paid to changes preceding an event. The main goal of this work will be the development of a short-term prediction scheme which could predict an impending event such that in the clinical setting preventions/interventions, like electrical therapies may be performed.