Acquisition of Mass Spectrometers and X-ray Diffractometer

来自化学研究仪器和设施(CRIF)和主要研究仪器(MRI)计划的这一奖项将使芝加哥大学化学系获得两台质谱仪和一台X射线衍射仪。该设备将加强一些领域的研究，包括：大型多电荷金属络合物的研究，重点是双金属络合物和超分子组装及其客体结合；立方烷类似物的合成；高压材料的研究；极小的活性氮氢化物的合成和研究；镍(II)体系中还原消除反应的研究；亲电金属络合物的化学；分子识别；生物有机化学和化学生物学；作为模型表面的烷基硫醇在金上的自组装单分子膜，用于了解和控制哺乳动物细胞与底物的相互作用；生物催化，例如核酶催化的磷转移反应；卡宾络合物的中到大环合成；以及新型功能和多功能聚合物和分子的合理设计、合成和表征。质谱仪(MS)是一种用于探测大量有机、生物有机和有机金属分子的内部结构细节和获得其分子组成的技术。X射线衍射仪可以精确和精确地测量分子的全部三维结构，包括键的距离和角度，并提供关于分子相对于邻近分子的空间排列的准确信息。这套仪器将促进生物化学、材料科学、普通合成化学以及生物和地球物理科学的研究。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) and the Major Research Instrumentation (MRI) Programs will allow the Department of Chemistry at the University of Chicago to acquire two mass spectrometers and an X-ray diffractometer. This equipment will enhance research in a number of areas, including studies of large multi-charged metal complexes with an emphasis on bimetallic complexes and supramolecular assemblies and guest incorporation; synthesis of cubane analogs; studies of materials at high pressures; synthesis and study of very small, reactive hydrides of nitrogen; investigations of reductive elimination reactions in nickel(II) systems; chemistry of electrophilic metal complexes; molecular recognition; bioorganic chemistry and chemical biology; self-assembled monolayers of alkanethiolates on gold as model surfaces for understanding and controlling mammalian cell-substrate interactions; biological catalysis, for example, phosphoryl transfer reactions catalyzed by ribozymes; medium to large ring synthesis with carbene complexes; and the rational design, synthesis and characterization of novel functional and multifunctional polymers and molecules. Mass spectrometry (MS) is a technique used to probe intimate structural details and to obtain the molecular compositions of a vast array of organic, bioorganic, and organometallic molecules. The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. This suite of instruments will facilitate research in biological chemistry, materials science, and general synthetic chemistry, as well as biological and geophysical sciences.