Function and transcriptional regulation of a plant detoxification program

植物受到有毒化学物质的挑战，这些有毒化学物质要么是由人类、邻近的植物释放的，要么是病原微生物释放的。此外，在不利的非生物条件或病原体攻击下产生的氧化应激条件下，内源反应分子会积累。一组可诱导的解毒酶和转运蛋白有助于灭活和消除有害的外来或内源性物质。INA(2，6-二氯异烟酸)、2，4-D(2，4-二氯苯氧乙酸)和TIBA(2，4，6-三碘苯甲酸)等外源物质以及高水平的水杨酸都可以触发至少部分解毒计划的激活。我们已经表明，bZIP转录因子的TGA家族和相互作用的Gras蛋白SCL14对这种激活是重要的(Fode等人，2008年)。我们的目标是进一步深入了解SCL14/TGA依赖于化学胁迫植物的转录调控机制，并确定这一途径对于限制疾病或胁迫症状的重要性。

Plants are challenged by toxic chemicals that are either released by man, neighboring plants or pathogenic microbes. Moreover, endogenous reactive molecules accumulate under conditions of oxidative stress generated under adverse abiotic conditions or pathogen attack. Inactivation and elimination of harmful xenobiotic or endogenous substances is facilitated by an inducible set of detoxifying enzymes and transporters. Activation of at least part of this detoxification program can be triggered by xenobiotics like INA (2,6-dichloroisonicotinic acid), 2,4-D (2,4-dichlorophenoxyacetic acid) and TIBA (2,4,6-triiodobenzoic acid), as well as by high levels of salicylic acid. We have shown that the TGA family of bZIP transcription factors and the interacting GRAS protein SCL14 are important for this activation (Fode et al., 2008). We aim to obtain further insight into SCL14/TGA-dependent transcriptional control mechanisms in chemically stressed plants and to determine the importance of this pathway for the restriction of disease or stress symptoms.