Selective Extraction with Molecular Recognition in Fluorous Media

该项目由分析和表面化学计划赞助，开发无需挥发性溶剂的化学选择性萃取材料和方法。这项研究由匹兹堡大学的斯蒂芬·G·韦伯博士和他的学生进行，开发了新型氟膜和薄膜，在这些薄膜上，氟聚合物支撑着一种含氟的非挥发性溶剂。膜是由特氟龙(TM)AF2400和五种增塑剂制成的，以形成支撑的氟相。这些支撑相被掺入分子识别受体，使氟相对各种目标物种的提取具有高度的选择性。使用分配实验和红外光谱测量来定量特定官能团对分配到氟相中的影响。这些实验的结果被用来指导人工受体的设计和开发受体文库。这个项目的结果如果得到充分利用，可能会产生广泛的影响。潜在的应用包括改进药品的化学分析，减少某些行业的能源消耗，以及减少分析实验室样品加工造成的浪费。

This project, sponsored by the Analytical and Surface Chemistry Program, develops materials and methods for chemically selective extraction without the need for volatile solvents. The research, conducted by Dr.Stephen G. Weber and his students at the University of Pittsburgh, develops novel fluorous membranes and films on which a fluoropolymer supports a fluorous nonvolatile solvent. Membranes are prepared from Teflon (TM) AF2400, and five plasticizers to form the supported fluorous phases. These supported phases are doped with molecular recognition receptors that allow the fluorous phases to be highly selective for extraction of various target species. Partitioning experiments and infrared spectroscopic measurements are used to quantitate the influence of a particular functional group on partitioning into the fluorous phase. The results of these experiments are used to guide the design of artificial receptors and to develop libraries of receptors. The results from this project could have far ranging effects when fully utilized. Potential applications include improved chemical analysis for pharmaceuticals, reduced energy comsumption in some industries, and a reduction in waste from sample processing in analytical laboratories.