Crosstalk between cell survival and cell death pathways

该项目旨在确定决定细胞命运的精确分子机制。细胞存活(自噬)和细胞死亡(凋亡)之间的动力学是复杂的，涉及到这些途径之间的显著串扰。这对细胞过程至关重要。自噬和细胞凋亡的异常控制影响到所有生物的功能，以及从癌症到心脏病的各种疾病的发展和治疗。这个项目致力于促进我们对连接自噬和细胞凋亡的蛋白质的理解。这些结果有望解释细胞如何决定它们的命运，并为未来治疗疾病的策略的发展提供信息。

This project aims to determine the precise molecular mechanisms underlying cell fate decisions. The dynamics between cell survival (autophagy) and cell death (apoptosis) are complex, involving significant crosstalk between these pathways. This is fundamentally important to cellular processes. Aberrant control of autophagy and apoptosis affects the function of all organisms as well as the development and treatment of diseases ranging from cancer to heart disease. This project endeavours to advance our understanding of the proteins that interconnect autophagy and apoptosis. The results are expected to explain how cells determine their fate and inform future development of strategies to treat disease.