RUI: Fabrication, Characterization and Applications of New Separation Media

圣何塞州立大学的Joseph Pesek教授是由分析和表面化学计划通过RUI赠款赞助的，用于研究新分离介质的制造、表征和应用。这项研究将导致开发新的底物用于高效液相色谱、毛细管电泳法(CE)、毛细管电色谱(CEC)和固相微萃取(SPME)，以改善分离效果。第一部分的工作集中在二氧化硅和其他具有有机部分的氧化物表面的化学修饰，特别是炔烃。还将用液晶化合物进行化学修饰。第二部分重点介绍了增加比表面积的刻蚀工艺，以及这些材料在开管CEC分离(OTCEC)和SPME配置中的后续应用。OTCEC将被开发用于改善蛋白质、多肽和药物的分离。分离生物化合物的能力在医学研究和基因组学以及化学和制药工业中具有重要意义。接触这项工作将使圣何塞的学生(其中许多人来自代表性不足的群体)能够进入国家需要的这些领域的技术职位。

Professor Joseph Pesek of San Jose State University is sponsored by the Analytical and Surface Chemistry Program via a RUI grant for research on fabrication, characterization and applications of new separation media. The research will lead to the development of new substrates for HPLC, capillary electrophoresis (CE), capillary electrochromatography (CEC), and solid phase microextraction (SPME) for the purpose of improved separations. The first part of the work focuses on chemical modification of silica and other oxide surfaces with organic moieties, especially alkynes. Chemical modification will also be achieved with liquid crystal compounds. The second part focuses on etching processes for the purpose of increased surface area, and subsequent application of these materials to open tube CEC separations (OTCEC) and SPME configurations. OTCEC will be developed for improved separation of proteins, peptides and pharmaceuticals.The ability to separate biological compounds is of great importance in medical research and genomics, as well as in chemical and pharmaceutical industry. Exposure to this work will enable San Jose students (many of whom are from under-represented groups) to enter technical positions in these areas of national need.