Peroxide Reaction Mechanisms

在有机化学和高分子化学项目的支持下，范德比尔特大学化学系的Ned Porter教授正在研究有机化合物的过氧化反应机理和有机过氧化化合物的化学。分析过氧化合物的新方法(银配位离子喷雾质谱仪与高效液相色谱联用)与并行计算分析相结合，导致了从过氧酸及其共轭碱中高能获得的二氧六环的研究。将制备一类新的化合物--吡啶二醇，并对其抗氧化性能进行研究。作为自由基引发剂的新偶氮化合物将允许评估这些化合物在人类低密度脂质体中作为抗氧化剂的作用。理论和实验将共同致力于化合物的开发，这种化合物将把脂类可溶的过氧基转化为水溶性的超氧阴离子自由基，从而充当自由基链从有机亲脂聚集体到水的“输出”剂。许多有机化合物与分子氧反应生成过氧化氢产品，这一过程既具有商业意义，又与人类健康有关。范德比尔特大学化学系的Ned Porter教授得到了有机化学和高分子化学项目的支持，他研究了这一过程的化学机制，称为自氧化或过氧化，以及过氧化氢化合物的化学。他的研究还涉及自氧化的抑制和新抗氧化剂的研究。通过计算和实验研究的结合，波特教授正在开发具有潜在活性的新化合物，作为抗氧化剂和将氧化剂活性从导致细胞损害的细胞膜转移到水中的试剂，在水中，活性可以在不造成损害的情况下排放。

With the support of the Organic and Macromolecular Chemistry Program, Professor Ned Porter, of the Department of Chemistry at Vanderbilt University, is studying the mechanism of peroxidation reactions of organic compounds and the chemistry of organic peroxides. New methods for the analysis of peroxides (silver coordination ion spray mass spectrometry coupled to HPLC), coupled with parallel computational analyses, have led to the investigation of dioxiranes, energetically accessible from peroxy acids and their conjugate bases. A new class of compounds, pyri(mi)dinols, will be prepared and studied for their antioxidant properties. New azo compounds that serve as radical initiators will permit the evaluation of these compounds as antioxidants in human low density liposomes. Theory and experiment will together be used to target the development of compounds which will convert a lipid soluble peroxyl radical into a water soluble superoxide radical, thereby acting as agents for the "export" of a free radical chain from an organic lipophilic aggregate into water.Many organic compounds react with molecular oxygen to give peroxide products, a process that has both commercial importance and relevance to human health. Professor Ned Porter, of the Department of Chemistry at Vanderbilt University, is supported by the Organic and Macromolecular Chemistry Program for his study of the mechanism of the chemistry of this process, called autoxidation or peroxidation, and the chemistry of peroxide compounds. His studies also address the inhibition of autoxidation and the study of new antioxidants. Through a combination of calculational and experimental studies, Professor Porter is developing new compounds of potential activity as antioxidants and as agents for the transferral of oxidant activity from the cell membrane, where it causes cellular damage, to water, where the activity may be discharged without causing damage.