Protein self-assembly on surfaces, interfaces and nanoparticles

气液界面或气载纳米颗粒等表面对蛋白质在生物环境中的聚集有重要影响。我们将开发一种全面的理论和实验方法来研究这种表面对导致疾病的淀粉样纤维的蛋白质自组装的影响。这将从分子水平上理解蛋白质的自结合，并为设计阻止蛋白质聚集的抑制剂提供合理的依据。这项工作还将通过蛋白质在表面的受控自组装建立新的纳米材料的设计原则。

Surfaces such as those presented by an air-liquid interface or air-borne nanoparticles exert significant effects on protein aggregation in biological environments. We will develop a comprehensive theoretical and experimental approach to study the effects of such surfaces on the self assembly of proteins leading to disease causing amyloid fibrils. This will provide a molecular level understanding of protein self-association and a rational basis for the design of inhibitors to stop protein aggregation. The work will also establish design principles for new nanomaterials via the controlled self assembly of proteins on surfaces.