The MYB gene as a model for global transcriptional regulation: stopping, starting and looping

这个项目将研究转录延长是如何控制MYB基因的，MYB基因是正常和癌症生长和调节的关键调节因子。拟议的研究可能带来三大好处，它将通过在澳大利亚建立基因表达领域的研究能力，特别是在转录延长和长范围调控方面的研究能力，加强在转录调控的新的重要领域的研究。它将突出MYB在癌症中的治疗靶向的新方法：这项研究产生的数据可能使我们能够通过抑制转录延伸来靶向MYB在包括乳腺癌在内的一系列癌症中的表达。它还将为博士后科学家和学生提供高级分子生物学方面的培训。

This project will study how transcriptional elongation controls the MYB gene, a key regulator of normal and cancerous growth and regulation. There are three major benefits that are likely to flow from the proposed research It will strengthen research in new and important areas of transcriptional regulation, by building research capacity in Australia in the area of gene expression, particularly with respect to transcriptional elongation and long-range regulation. It will highlight a new approach to the therapeutic targeting of MYB in cancer: data generated from this research may enable us to target MYB expression in a range of cancers including breast cancer by inhibiting transcriptional elongation. And it will provide training in advanced molecular biology to postdoctoral scientists and students.