MRI: Acquisition of a 300 MHz FT-NMR for Undergraduate Research and Training

阿勒格尼学院化学系将从主要研究仪器(MRI)计划获得这一奖项，从而获得一台300 MHz傅立叶变换核磁共振(FT-核磁共振)光谱仪。该设备将使研究人员能够开展以下研究：a)开发合成砜的新方法；b)合成天然产物；c)研究金属蛋白质中的活性中心；d)开发根据序列预测RNA结构稳定性的模型；e)开发新的络合物，以催化与生物、化学和环境有关的氧化反应。这一工具将用于本科生的研究和课程范围内。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对包括环境化学和生物化学在内的许多领域产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Allegheny College will acquire a 300 MHz Fourier-Transform Nuclear Magnetic Resonance (FT-NMR) Spectrometer. This equipment will enable researchers to carry out studies on a) development of new methods for the synthesis of sulfones; b) synthesis of natural products; c) study of active centers in metalloproteins; d) development of models to predict the stability of RNA structure from sequence; e) development of novel complexes to catalyze oxidation reactions of biological, chemical and environmental relevance. This instrument will be used for undergraduates in their research and also within the curriculum. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including environmental chemistryand biochemistry.