Collaborative Research in Chemistry (CRC): Laboratory for Molecular Sciences (LMS): Caltech's Multi-Disciplinary Activities

化学部的这一奖项支持了加州理工学院的Ahmed Zewail教授及其同事在分子科学实验室（LMS）继续进行研究计划的研究。LMS是一个多学科研究实验室，用于研究复杂分子系统中的基本过程，在结构和动力学方面具有原子尺度的分辨率。 时间分辨衍射和成像方法的发展代表了一个主要的焦点，检查结构及其随时间的变化，实验和理论。 LMS的研究计划涉及加州理工学院的几名教师，他们将合作研究表现出广泛复杂性的化学和生物系统。 这些教师来自几个学科部门，如化学，物理，生物和工程。 实验室配备了最先进的超快激光器、高速计算机、生化和电化学仪器以及质谱仪。 研究课题包括分子识别、大分子瞬时结构变化、电化学催化、纳米结构和光镊成像。在过去的二十年里，在获得原子尺度的化学体系的空间和时间分辨率方面取得了巨大的进步。 这种能力为许多学科的分子结构和动力学研究提供了新的机会。 从反应和蛋白质折叠的基本动力学到分子组装和凝聚相的动力学，原子分辨率基本尺度的理论和实验为理解分子功能和材料特性提供了关键。 分子科学领域正处于一场革命之中，特别是在化学和生物学之间的界面，新的实验工具，如LMS正在开发和使用的工具，用于阐明复杂分子系统的结构和动力学。

This award from the Division of Chemistry supports the research of Professor Ahmed Zewail and colleagues at the California Institute of Technology for continuation of a program of research at the Laboratory for Molecular Science (LMS). The LMS is a multidisciplinary research laboratory for studying fundamental processes in complex molecular systems with atomic scale resolution in both structure and dynamics. The development of time-resolved diffraction and imaging methods represents a major focus for examining structures and their changes with time, both experimentally and theoretically. The research program at the LMS involves several members of the Cal Tech faculty who will collaborate to examine chemical and biological systems exhibiting a wide range of complexity. These faculty come from several disciplinary departments, such as chemistry, physics, biology, and engineering. The Laboratory is equipped with state-of-the-art ultrafast lasers, high-speed computers, biochemical and electrochemical instrumentation, and mass spectrometry. Research topics to be examined include molecular recognition, macromolecular transient structural changes, electrochemical catalysis, nanostructures, and imaging by optical tweezers.Over the last two decades great strides have been made in attaining both spatial and temporal resolution of chemical systems down to the atomic scale. This capability has provided new opportunities for studying molecular structure and dynamics in many disciplines. From the elementary dynamics of reactions and protein folding to the dynamics of molecular assemblies and condensed phases, theory and experiment at the fundamental scale of atomic resolution provides the key to understanding molecular function and materials properties. The field of molecular sciences is in the midst of a revolution, especially at the interface between chemistry and biology, where new experimental tools, such as those being developed and used at the LMS, are used to elucidate the structure and dynamics of complex molecular systems.