Collaborative Proposal -- ITR/SY Molecular Computational with Automated Microfluidic Sensors (MCAMS)

EIA-0121368 Alivisatos，Paulof California-BerkeleyCollaborative Prosposal-ITR/SY：使用自动化微流控传感器的分子计算\(MCAMS\)普林斯顿大学、斯坦福大学和加州大学伯克利分校的这个跨学科项目的主要目标是将微流控技术与最近开发的基于RNA的计算算法相结合，创建一种紧凑、自动化的基于核苷酸的计算设备，能够快速检测计算输出。这种装置的实现不仅将极大地影响分子计算领域，而且还将极大地影响一般分子生物学领域，因为所提出的平台技术将为生物研究提供新的、先进的工具。该项目正在解决三个主要问题：-微流控装置是否可以用于基于RNA的计算？-是否可以使用替代的检测方法来避免基于RNA的计算中的劳动密集型读出步骤？-这些检测方法是否可以应用于一般生物研究中遇到的其他问题？该项目的成功将代表着在分子计算方向上的一次飞跃。此外，它还将提供必要的平台技术，以加快生物研究，特别是在DNA快速测序和指纹识别领域。

EIA-0121368Alivisatos, PaulUniversity of California-BerkeleyCollaborative Prosposal-ITR/SY: Molecular Computational with Automated Microfluide Sensors\(MCAMS\) The main objective of this cross-disciplinary project between Princeton University, Stanford University and UC Berkeley is to combine microfluidic technology with recently-developed algorithms of RNA-based computing to create a compact, automated nucelotide-based computational device capable of rapid detection of the computational output. Realization of such a device would greatly impact not only the field of molecular computing but also the general field of molecular biology, as the proposed platform technologies would provide novel, advanced tools for biological research.The project is addressing three main questions: - Can a microfluidic device be used to automate RNA-based computation? - Can alternative detection methods be used to avoid labor-intensive readout steps in RNA-based computation? -Can these detection methods be applied to other problems encountered in general biological v research? The success of this project will represent a leap forward in the direction of "hands-free" molecular computation. In addition, it will provide the necessary platform technologies to accelerate biological research, particularly in the areas of rapid DNA sequencing and fingerprinting.