Fine Tuning Photochemical Reactions Through Confinement and Cation-Organic Interactions

PI寻求继续他的工作，使用沸石来帮助实现非对映选择性和对映选择性光化学反应。PI认为，沸石笼中的阳离子以及光反应分子和手性助剂对不对称光反应的成败起着至关重要的作用。阳离子的存在，离子浓度的存在，手性感应器或辅助剂的存在都会有系统的变化。项目期间的主要目标是利用这些信息开发一个模型，帮助人们预测和计划沸石中的对映选择性光反应。通过这一奖项，有机和高分子化学项目支持杜兰大学化学系V.Ramamurthy博士的研究。拉马穆尔蒂博士将致力于利用沸石来促进不对称光化学反应。要研究的光化学反应产生的分子是手性的(有两个不可重叠的镜像)，并且只产生两种可能形式中的一种(单一对映体)。这类反应的发展是当今制药行业面临的最重要的问题之一。开发出来后，拉马穆尔蒂博士的工作可以应用于许多生物活性分子的合成。在这项工作过程中接受培训的学生将获得制药业所需的技能，制药业现在生产许多单一的对映体化合物。

The PI seeks to continue his work in the use of zeolites to help effect diastereoselective and enantioselective photochemical reactions. The PI proposes that the cations which are present in the zeolite cage, along with the photoreactive molecule and chiral auxiliary, are critical to the success or failure of the asymmetric photoreactions. Cations present, hydronium ion concentrations present, and chiral inductors or auxiliaries present will be systematically varied. The main goal of the project period is to use this information to develop a model to help one predict and plan enantioselective photoreactions within zeolites. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. V. Ramamurthy of the Department of Chemistry at Tulane University. Dr. Ramamurthy will work on using zeolites to facilitate asymmetric photochemical reactions. The photochemical reactions to be studied produce molecules which are chiral (have two nonsuperimposable mirror images) and make only one of the two possible forms (a single enantiomer). Development of this family of reactions is one of the most important problems facing the pharmaceutical industry today. When developed, Dr. Ramamurthy's work could be applied to the syntheses of a number of biologically active molecules. Students trained during the course of this work will gain skills needed by the pharmaceutical industry which now produces a number of single enantiomer compounds.