From Solid State Reaction Mechanisms to Green Chemistry

这项研究的重点是使用光化学方法合成结晶状态的有机化合物。脂肪酮的光脱甲基化生成双自由基和重氮化合物的分解有望导致环状化合物和单线态卡宾的容易进入，这是有用的合成中间体。对反应途径的机理研究将有助于揭示固体中的自由基二聚和氢的提取过程。Garcia-Baribay博士的教育工作重点是培养研究生、本科生和博士后化学家，其中许多人来自非传统和弱势背景。通过这个续展奖项，有机和高分子化学项目正在支持加州大学洛杉矶分校化学和生物化学系Miguel A.Garcia-Garibay博士的研究和教育努力。加西亚-加里巴伊教授将把他的工作重点放在开发可以用光作为试剂的固态化学过程上。这些过程将允许在不使用可能污染环境的溶剂或重金属的情况下合成复杂的有机化合物。由此产生的“绿色化学”有望为制药公司所用。该奖项的教育活动将增加加州大学洛杉矶分校女性和拉美裔学生的机会。

The focus of this research is the use of photochemical methods for the synthesis of organic compounds in the crystalline state. Photodecarbonylation of aliphatic ketones to produce biradicals and the decomposition of diazo compounds is expected to lead to facile entry to cyclic compounds and singlet carbenes that are useful synthetic intermediates. Mechanistic studies of the reaction pathways will shed light on radical dimerization and hydrogen abstraction processes in the solid state. Dr. Garcia-Baribay's educational efforts focus on the training of graduate, undergraduate and post-doctoral chemists, many who come from non-traditional and disadvantaged backgrounds.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Miguel A. Garcia-Garibay in the Department of Chemistry and Biochemistry at UCLA. Professor Garcia-Garibay will focus his work on the development of chemical processes that can be performed in the solid state with light as a reagent. These processes will allow the synthesis of complex organic compounds without the use of solvents or heavy metals that can pollute the environment. The resulting "green chemistry" is expected to be of use by pharmaceutical companies. The educational activities of the award will enhance opportunities for women and Hispanic students at UCLA.