Chemical synthesis of cancer-associated glycoproteins

蛋白质糖基化是一种极其常见的事件，在多种生物过程中起着重要的作用。糖蛋白的异常糖基化和过度产生与多种癌症类型(包括乳腺癌、前列腺癌、卵巢癌和小肺癌)有关，并被认为是疾病诊断和疫苗开发的有前途的药物。在这项研究计划中，将使用一些新的化学技术来合成一系列与癌症相关的糖蛋白。这些糖蛋白将用于开发癌症疫苗和诊断。癌症是澳大利亚社区和经济的沉重负担，因此这项研究将对澳大利亚产生重大好处。

Glycosylation of proteins is an extremely common event which plays an important role in a variety of biological processes. Aberrant glycosylation and over-production of glycoproteins is associated with numerous cancer types (including breast, prostate, ovarian and small lung) and are recognised as promising agents for disease diagnosis and vaccine development. A range of cancer-associated glycoproteins will be synthesised in this research program using a number of novel chemical technologies. These glycoproteins will be used to develop cancer vaccines and diagnostics. Cancer is a severe burden on the Australian community and on the economy, therefore this research will be of significant benefit to Australia.