Carbon-Carbon Bond-Forming and -Cleaving Stoichiometric and Catalytic Organometallic Reactions

本研究的重点是探索和系统地研究有机过渡金属，包括钯，锆，镍和铝的1，2-迁移插入过程。 该方法的中心主题是使用Pd和Zr作为催化剂来生产烷基铝。 所得烷基铝是合成有用的中间体。 教育工作的重点将是培训学生掌握生成和操作空气敏感材料的必要技术。 有了这个更新奖，有机和高分子化学计划正在支持Ei-ichi Negishi博士的研究和教育工作。 Negishi教授将把工作重点放在金属作为催化剂和中间体的使用上，以产生新的碳-碳键。 正在开发的新方法将允许在实验室中将廉价的起始材料转化为有价值的药物中间体，预计将对制药公司制造药物的方式以及化学工业生产各种重要化合物的方法产生影响。

The focus of this research is to explore and systematically investigate 1,2-migratory insertion processes of organotransition metals, including palladium, zirconium, nickel and aluminum. The central theme of the approach is the use of Pd and Zr as catalysts to produce alkyl aluminums. The resulting alkyl aluminums are synthetically useful intermediates. The focus of the educational effort will be the training of students in the necessary techniques for the generation and manipulation of air-sensitive materials. With this Renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Ei-ichi Negishi. Professor Negishi will focus his work on the use of metals as catalysts and intermediates in order to produce new carbon-carbon bonds. The new methods being developed will permit the conversion of inexpensive starting materials into valuable pharmaceutical intermediates in the laboratory, and are expected to have an impact on the way in which pharmaceutical companies manufacture drugs, and on the methods used by the chemical industry to produce a variety of important chemical compounds.