Macromolecular Structure Database (MSD)

蛋白质数据库(PDB)是有关生物大分子结构信息的唯一国际储存库和主要来源。因此，它是一个关键的研究资源，也是我们理解生命系统的核心组成部分。PDB为实验、结构和计算科学家的广泛社区提供服务，并为各级教育工作者提供资源。PDB访问是通过主要网站和ftp站点(www.pdb.org，ftp.pdb.org)或通过分布在世界各地的7个镜像站点提供的。结构生物学研究合作实验室(RCSB)管理PDB的目标是提供一个单一的、可搜索的、关于实验确定的大分子结构的准确和注释良好的数据档案。RCSB开发的系统目前正用于数据处理、存档、分发和查询，以及实物档案的维护。在本项目期内，计划开展的新活动如下。首先，正在改进数据处理，提高处理的准确性和速度，确保整个档案尽可能统一和无差错，并建立支持自动数据存储和交换功能的基础设施。第二，正在改进数据归档、分发和查询能力，办法是实施一个新的系统来分发和归档所有的PDB数据，并能够进行全面的结构性数据分析，而不受地理位置、当地硬件或软件配置的影响。最后，正在完成和维护一个全面的实物档案，以确保保存原始数据和与数据库交易有关的所有记录，包括描述其演变和维护的文件。这一努力的结果将是蛋白质数据库对专家和非专家的效用和价值都有了显著的改善。增加这项工作更广泛影响的机制包括：举办一系列讲习班和会议，积极参加科学会议，定期出版通讯，不断利用一个服务台，为专家和非专家研究界提供更多的PDB，并利用重点小组确保最大限度地利用PDB数据。正在利用参与研究生和本科生课程设计和实施以及有组织的研究机会来增加PDB对大学教育的影响。参加教师培训研讨会和共同努力启动教师发展计划，提供了将PDB资源带到K/12环境的机会。公众正在通过巡回艺术展以及频繁的新闻发布和信息节目了解PDB的努力。总体而言，这些努力将把临时局的资源和活动的好处扩大到尽可能广泛的社区。

The Protein Data Bank (PDB) is the single international repository and primary source for information about the structure of biological macromolecules. As such, it is a key research resource and a central component to our understanding of living systems. The PDB serves a broad community of experimental, structural and computational scientists and serves as a resource for educators at all levels. PDB access is provided through primary web and ftp sites (www.pdb.org, ftp.pdb.org) or via 7 mirror sites distributed worldwide. The goal of the Research Collaboratory for Structural Biology (RCSB) in managing PDB is to provide a single, searchable archive of accurate and well-annotated data on experimentally determined macromolecular structure. Systems developed by RCSB are currently being used for data processing, archiving, distribution and query, as well as maintenance of the physical archive. In the current project period, new activities are planned as follows. First, data processing is being improved by increasing accuracy and speed of processing, ensuring that the entire archive is as uniform and error free as possible, and creating the infrastructure to support automated data deposition and exchange functions. Second, data archiving, distribution and query capabilities are being improved by implementing a new system for distribution and archiving of all PDB data, and enabling comprehensive structural data analyses regardless of geographic location, local hardware, or software configuration. Finally, completion and maintenance of a comprehensive physical archive is being undertaken to ensure the preservation of primary data and of all records associated with the transactions of the database including documents describing its evolution and maintenance. The result of this effort will be a significant improvement in the utility and value of the Protein Data Bank for both specialists and non-specialists alike. Mechanisms for increasing the broader impacts of this work include the following: a series of workshops and meeting sessions, active participation in scientific meetings, a regular newsletter, the on-going use of a help desk to increase the access and utility of PDB for the specialist and non-specialist research community, and use of focus groups to insure maximum usability of PDB data. Participation in graduate and undergraduate coursework design and implementation and in structured research opportunities is being used to increase the impact of PDB on university-level education. Participation in teacher training workshops and a collaborative effort to launch a teacher development program provide opportunities to bring PDB resources to the K/12 environment. The general public is being made aware of PDB efforts through a traveling art exhibit and through frequent news releases and informational programs. Collectively, these efforts will extend the benefits of PDB resources and activities to the broadest possible community.