Resolution of the Kinetics of Bimolecular Organic Reactions in Solution

在化学学部有机动力学项目的支持下，犹他州立大学的弗农·d·帕克教授将继续过去五年的工作，利用非稳态动力学方法来证明，一些长期以来被认为是通过简单的单步二阶机制发生的反应实际上更复杂，并且通过具有动力学意义的反应中间体进行。非稳态动力学方法是基于这样的观察，即迄今为止所研究的双分子反应都是通过可逆的连续二阶机制发生的，其中包括具有动力学意义的反应中间体。新开发的机制探针将用于检测SN2，消除，亲核芳香取代，基团转移和Diels-Alder反应。研究结果有望大大提高对双分子有机反应机理的认识。结果也有望纠正基于所有这些反应通过单一过渡态从反应物到产物的信念的误解。化学学部的有机和大分子化学项目支持犹他州立大学的Vernon D. Parker教授，他将挑战人们公认的观点，即作为物理有机化学主干的双分子反应遵循简单的单步机制，在反应物和产物之间的反应坐标上有单一的过渡态。尖端研究将培养本科生、研究生和研究生，他们将参与最先进的研究项目。帕克教授将在高质量的期刊上发表这项工作的结果，并举办有关结果的研讨会，并发表评论文章，将结果纳入背景。将与美国研究人员和国外研究人员开展合作项目。

With the support of the Organic Dynamics Program in the Chemistry Division, Professor Vernon D. Parker at Utah State University will continue work carried out over the past five years that employed non-steady-state kinetic methods to show that a number of reactions long believed to take place by simple single-step second-order mechanisms are actually more complex and proceed via kinetically significant reaction intermediates. The non-steady-state kinetic method developed in the previous grant period is based upon the observation that the bimolecular reactions examined thus far all take place by the reversible consecutive second-order mechanism involving kinetically significant reaction intermediates. New mechanistic probes developed will be used to examine SN2, elimination, nucleophilic aromatic substitution, group transfer, and Diels-Alder reactions. The research suggested is expected to greatly increase the understanding of bimolecular organic reaction mechanisms. Results are also expected to correct misconceptions based upon the belief that all of these reactions proceed from reactant to product via a single transition state.The Organic and Macromolecular Chemistry Program in the Chemistry Division supports Professor Vernon D. Parker at Utah State University who will challenge the accepted belief that the bimolecular reactions that are the backbone of Physical Organic Chemistry follow simple single-step mechanisms with single transition states on the reaction coordinate between reactants and products. The cutting-edge research will train undergraduate, graduate and postgraduate students who will take part in state-of-the-art research on projects of general interest. Professor Parker will publish the results of this work in high quality journals as well as present seminars on the results, and publish review articles to bring the results into context. Collaborative projects with US researchers and researchers from abroad will be developed.