Multiparametrische Analyse der Korrelation perzeptiver und kognitiver neuronaler Signale durch Integration von Magnetoenzephalographie und 3T-funktioneller Kernspintomographie

具有高时间和空间分辨率的神经成像方法的集成是人脑神经科学的重要目标。在这里提出的项目中，我们计划进行一系列的实验，以整合功能磁共振成像和脑磁图的感官知觉以及认知领域。我们将进行实验的方法发展的目的，也探索特定的生理假设。我们的方法是创新的，因为我们将以定量的方式探测BOLD信号和神经MEG信号的相关性。因此，我们将作出贡献的电生理和血流动力学措施之间的联系的主要理解。此外，我们将能够测试某些特定的假设，否则将无法接受。在这个项目中，我们将集中在听觉知觉和工作记忆领域的颞叶和前额叶皮层。

The integration of neuroimaging methods with high temporal and spatial resolution is an important goal for neuroscience of the human brain. In the project proposed here we plan a series of experiments to integrate fMRI and MEG for sensory perception as well as cognitive domains. We will perform experiments for methodological development purposes and also to probe specific physiological hypotheses. Our approach to this is innovative in that we will probe the correlation of BOLD signals and neural MEG signals in a quantitative fashion. Thus we will make a contribution to a principal understanding of the link between electrophysiological and hemodynamic measures. In addition, we will be able to test certain specific hypotheses that would not be amenable otherwise. In this project we will focus on the auditory perceptual and working memory domains in temporal and prefrontal cortices.