Organic and Organometallic Chemistry

这个奖项在无机，生物无机和有机化学计划支持研究教授罗伯特G。Bergman在伯克利的加州大学的研究，以获得对金属络合物和有机化合物在均相溶液中使用新的和已知的带有金属-杂原子单键的后过渡金属络合物的反应的基本机理理解。 该项目建立在用于合成母体的潜在通用方法（即，N-未取代的）低价的后过渡金属氨基化物配合物，并将其扩展到涉及氮或磷的其他化合物。 具体的研究目标包括：（a）合成和研究范围更广的母体金属酰胺，（B）制备相关化合物，如金属酰肼配合物，并检测它们的反应性，（c）开发催化烯烃和炔加氢胺化的新方法，（d）金属酰胺在伯胺选择性合成中的应用，（e）研究金属酰胺催化的异构化反应，以及（f）将酰胺基化学中开发的方法扩展到母体膦基络合物的合成，包括它们在P-手性膦的不对称合成中的应用。 这些项目将由本科生、研究生和博士后研究员进行，他们在本研究期间获得的培训将有助于他们今后的工作。本研究探讨均相催化的基本方面，并为本科生、研究生和博士后参加先进的科学工作做好准备。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Robert G. Bergman at the University of California at Berkeley to obtain a basic mechanistic understanding of the reactions of metal complexes and organic compounds in homogeneous solution using both new and known late transition metal complexes that bear metal-heteroatom single bonds. The project builds on potentially general methods for the synthesis of parent (i.e., N-unsubstituted) low-valent, late transition metal amide complexes and extend it to others involving nitrogen or phosphorus. Specific research goals include: (a) the synthesis and study of a wider range of parent metal amides, (b) the preparation of related compounds, such as metal hydrazido complexes and an examination of their reactivity, (c) the development of new methods for catalytic alkene and alkyne hydroamination, (d) the use of metal amides in the selective synthesis of primary amines, (e) the study of metal amide-catalyzed isomerization reactions, and (f) the extension of methods developed in amido chemistry to the synthesis of parent phosphido complexes, including their use in the asymmetric synthesis of P-chirogenic phosphines. The projects will be carried out by undergraduate students, graduate students and postdoctoral fellows whose training obtained during the performance of this research will be useful in their future work.This research probes fundamental aspects of homogeneous catalysis and prepares undergraduate, graduate and postdoctoral students for participation in the advanced scientific workforce.