Chiral Magic-Number Clusters & Non-Covalent Complexes Studied by Electrospray Ionization & Ion Soft Landing

R教授普渡大学的Graham Cooks得到了分析和表面化学项目的支持，利用电声喷雾电离的软电离能力来产生质谱探测的分子簇。在将产物引入质量分析仪之前，这些簇的反应将在大气压下进行。团簇和产物在质量选择后“软着陆”到表面（液体和固体）上，并使用红外激光解吸进行检测。 这项工作的重点是在PI的实验室中发现的氨基酸丝氨酸的纯手性簇，以及手性放大和通过对映选择性化学反应将手性转移到其他物种的问题。非共价键是理解生物活性分子之间相互作用的重要课题，也是胶体化学和传感器等许多其他领域的重要课题。 因此，除了提供优秀的学生教育，PI继续开发质谱最终用于生物学和安全应用，例如。

Professor R. Graham Cooks of Purdue University is supported by the Analytical and Surface Chemistry Program to use the soft ionization capabilities of electrosonic spray ionization to generate molecular clusters probed by mass spectrometry. Reactions of these clusters will be carried out at atmospheric pressure prior to introduction of the products into a mass analyzer. Clusters and products are 'soft landed' onto surfaces (liquids and solids) after mass selection and detected using infrared laser desorption. The work focuses on the homochiral clusters of the amino acid serine discovered in the PI's laboratory, and on issues of chiral amplification and transfer of chirality to other species through enantioselective chemical reactions. Noncovalent bonding is an important topic in understanding interactions between biologically active molecules, as well as in many other areas including colloid chemistry and sensors. Thus, in addition to providing excellent student education, the PI continues to develop mass spectrometry ultimately for biology and security applications, for example.