Acquisition of an Agilent 1100 Series MALDI/LC TOF Mass Spectrometer for Three Collaborating Departments at Duquesne University

在重大研究仪器(MRI)计划的支持下，杜奎恩大学的化学和生物化学系将获得一台基质辅助激光解吸电离飞行时间(MALDI-TOF)液体色谱质谱计。该仪器将用于广泛的研究项目，包括a)有机和无机合成反应的研究；b)特定蛋白质与确定的遗传活性的关联；c)确定和利用生物标记物的离散条件或结果；d)各种类型的表面修饰的定量表征，从功能化的自组装单分子膜到指纹和遗传物质。基质辅助激光解吸电离(MALDI)飞行时间(TOF)质谱仪是获得高达300,000道尔顿及以上分子的精确分子质量的首选技术，具有极高的灵敏度。因此，使用MALDI-TOF质谱计已成为一种标准技术，特别是在涉及生物分子的研究中。这项研究将在多个领域产生重大影响，特别是生物化学、药物化学和材料科学。

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Duquesne University will acquire a Matrix-assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF) Liquid-Chromatograph Mass Spectrometer. This instrument will be used in a wide variety of research projects, including studies on a) organic and inorganic synthesis reactions; b) correlating specific proteins with defined genetic activity; c) identifying and exploiting the bio-markers for discrete conditions or outcomes; and d) quantitative characterization of various types of surface modifications, from functionalized self assembled monolayers to fingerprints and genetic material. Matrix-assisted laser desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry is the technique of choice for obtaining accurate molecular weights on molecules up to and over 300,000 daltons, with extremely high sensitivity. Use of a MALDI-TOF mass spectrometer has therefore become a standard technique, especially in studies involving biomolecules. This research will have a significant impact in a number of areas, especially biochemistry, medicinal chemistry and materials science.