Synthetic Organosulfur and Organoselenium Chemistry

本研究的重点包括九个目标。主要包括：1)合成新的、混合的含硒、硅、硫和锡的4-6和8-10元环；2)双环1,2-二硫原素的合成；3)含硫小鼠半化学物，新型（巯基）硅烷，以及与SPME纤维形成的伪物；4)香菇全合成香菇酸；5)合成具有生物学意义的1,2-二烯内酯；6) 5-杂双环[1.1.1]戊烷和2-硫双环-[1.1.0]丁烷的合成；7)生物活性有机硫化合物的硒类似物的合成；8)小有机硒化合物的微波表征；9)葱化学：光学活性烯和s -2-氟-2-丙烯硫衍生物的合成。有了这个奖项，有机和大分子化学项目支持了纽约州立大学奥尔巴尼分校化学系埃里克·布洛克博士的研究。布洛克教授将把他的工作重点放在寻求回答与元素硫和硒的化学有关的基本问题，这是生物系统的重要组成部分。该项目在制药业和人类健康领域具有更广泛的影响。此外，该项目是培养本科生、研究生和博士后同事的绝佳场所。

The focus of this research involves nine goals. Major aspects include: 1) synthesis of new, mixed selenium-, silicon-, sulfur-and tin-containing 4-6- and 8-10-membered rings; 2) synthesis of bicyclic 1,2-dichalcogenins; 3) sulfur-containing mouse semiochemicals, new (mercaptomethyl)silanes, and artifact formation with SPME fibers; 4) total synthesis of lentinic acid from shiitake mushrooms; 5) synthesis of biologically relevant 1,2-diselenolanes; 6) synthesis of 5-heterobicyclo[1.1.1]pentanes and 2-thiabicyclo-[1.1.0]butanes; 7) synthesis of selenium analogues of biologically active organosulfur compounds; 8) microwave characterization of small organoselenium compounds; 9) Allium chemistry: synthesis of optically active ajoene and S-2-fluoro-2-propenylthio derivatives. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Eric Block in the Department of Chemistry at SUNY at Albany. Professor Block will focus his work on seeking to answer fundamental questions relating to the chemistry of the elements sulfur and selenium, important constituents of biological systems. The project has broader impact in the pharmaceutical industry and in the area of human health. Further, the project is an excellent venue for the training of undergraduates, graduate students and postdoctoral colleagues.