NSF-Europe Materials Collaboration: New Functionalized Hybrid Systems for Drug Delivery

该奖项来自加州大学圣地亚哥分校材料研究部固态化学项目，旨在开发一种化学修饰的纳米晶体多孔硅或二氧化硅基质，以增加纳米级的高表面积和自由体积。将研究用贵金属、聚合物、蛋白质和硅烷醇衍生的二氧化硅来覆盖孔隙的化学反应，最终目标是开发一种在适当生理条件下缓慢释放药物的基质。多孔硅膜的高表面积和自由体积允许大量药物的装载，不同的药物将被纳入这些多孔硅的微观颗粒中。以特定的速度将药物输送到身体的特定部位是有效医学治疗的一个重要方面。提出的工作将包括将分子捕获到多孔纳米结构中的新方法，以及利用材料的光学特性监测多孔纳米结构的新方法。特别是，将制备一维光子晶体，其光谱特征可以报告所含药物的数量或类型。该提案是美国国家科学基金会（NSF）响应材料世界网络（Materials World Network）的征求而收到的，将与欧洲合作伙伴dr。Bernard Coq， Jean-Marie Devoisselle和Frederique Cunin来自法国蒙彼利埃CNRS催化材料和催化有机化学实验室。蒙彼利埃实验室在法国脂质体给药材料的开发和商业化方面发挥了重要作用。这个合作项目将把蒙彼利埃小组的药物输送专业知识与加州大学圣地亚哥分校研究小组的纳米材料设计专业知识结合在一起。这项工作将为纳米技术、生物技术和药物化学领域的本科生、研究生和博士后提供高度跨学科的教育。该奖项将开发具有更复杂功能的纳米材料，可用于更有效地向患者输送药物。蒙彼利埃实验室该项目的欧洲合作者在法国脂质体给药材料的开发和商业化方面发挥了重要作用。有了这个奖项，学生将参与圣地亚哥和蒙彼利埃实验室之间的短期和长期交流和研究。

This award from the Solid State Chemistry program in the Division of Materials Research to University of California San Diego is to develop a chemically modified matrix of nanocrystalline porous Si or SiO2 to increase the high surface area and free volume at the nanoscale. Chemistries to cap the pores with noble metals, polymers, proteins, and silica derived from silanols will be studied, with the ultimate goal of developing a matrix for the slow release of drug under appropriate physiological conditions. The high surface area and free volume in porous Si films would allow the loading of a large amount of drug, and different drugs will be incorporated into these microscopic particles of porous Si. Delivering drugs to specified locations in the body at specified rates is an important aspect of effective medical therapies. The proposed work will encompass new methods of trapping molecules into porous nanostructures, and new methods of monitoring the porous nanostructures using the optical properties of the materials. In particular, one-dimensional photonic crystals will be prepared whose spectral signatures can report on the amount or type of drug contained within. This proposal, which was received at NSF in response to Materials World Network solicitation, is for collaborative efforts with European partners Drs. Bernard Coq, Jean-Marie Devoisselle and Frederique Cunin of the CNRS Laboratoire de Materiaux Catalytiques et Catalyse en Chimie Organique in Montpellier, France. The Montpellier lab has played a major role in the development and commercialization of liposome-based drug delivery materials in France. This collaborative program will bring together the drug delivery expertise of the Montpellier group with the nanomaterials design expertise of the UC San Diego research group.The work will provide a highly interdisciplinary education to undergraduate, graduate, and post-doctoral students in the fields of nanotechnology, biotechnology, and pharmaceutical chemistry. Nanomaterials would be developed with this award with more sophisticated functions that could be used to more effectively deliver drugs to patients. The European collaborators of this project at the Montpellier laboratory had played a major role in the development and commercialization of liposome-based drug delivery materials in France. With this award, students will be involved in short-term and long-term exchanges and studies between the San Diego and the Montpellier labs.