Manufacturing of Drug Nano-Dispersions and Nano-Particles by Mechanochemical Synthesis

这项工作的研究目标是开发一种用于药物和其他有机化合物的制造工艺，称为机械化学合成（MCS）。由MCS制造的药物纳米颗粒预计将表现出显着改善的药理学特性，这将增加许多重要药物治疗的有效性。这项研究将通过开发低熔点有机化合物的MCS工艺，促进材料纳米制造的进步，并由制药行业内的记录需求驱动。纳米制造过程的开发和优化以及潜在的负责任现象的探索将得到解决。特别是，该项目将建立确保高再现性的条件，并开发生产控制策略/设备。来自德雷克塞尔大学的一个团队的分析和纳米级制造经验将与iCeutica Inc.的机械化学合成和设备设计经验相结合，提供了一个机会，以促进与工业界的合作，促进工业界和大学科学家之间的更好的理解，并有可能导致科学突破和制造业研究领域的技术成就。拟议的研究将有一个强大的教育组成部分，建立在A. J.德雷克塞尔纳米技术研究所在研究和教育的现有优势。该项目内的活动将被纳入现有的NSF支持的可再生能源和可再生能源单位方案。

The research objective of this effort is to develop a manufacturing process for drugs and other organic compounds known as mechanochemical synthesis (MCS). Drug nanoparticles manufactured by MCS are expected to exhibit significantly improved pharmacological properties which will increase the effectiveness of many important pharmaceutical treatments. This research will contribute to the advancement of materials nanomanufacturing by developing a MCS process for organic compounds with low melting points, and is driven by a documented need within the pharmaceutical industry. The development and optimization of a nanomanufacturing process and exploration of the underlying responsible phenomena will be addressed. In particular, this project will establish conditions for ensuring high reproducibility and develop the control strategy/equipment for production. The analytical and nanoscale manufacturing experience of a team from Drexel University will be combined with the mechanochemical synthesis and equipment design experience of iCeutica Inc., presenting an opportunity to promote collaboration with industry, fostering a better understanding amongst industry and university scientists, and potentially leading to scientific breakthroughs and technological accomplishments in the fields of manufacturing research. The proposed study will have a strong educational component, building on the existing strengths of the A.J. Drexel Nanotechnology Institute in research and education. Activities within this project will be integrated into existing NSF-supported RET and REU programs.