EAGER: Carbide Derived Carbons with Pore Structure and Surface Chemistry Designed for Selective Adsorption of Proteins
EAGER:具有孔结构和表面化学性质的碳化物衍生碳,专为选择性吸附蛋白质而设计
基本信息
- 批准号:0945230
- 负责人:
- 金额:$ 12.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-01 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
NON-TECHNICAL DESCRIPTION: Severe sepsis kills about the same number of people per day as lung or breast cancer. Since the inflammatory response in case of sepsis is driven by cytokines, their removal from blood brings under control the unregulated pro- and anti-inflammatory processes driving sepsis. Unlike dialysis and filtration, not to mention drug-based therapy, adsorption can remove cytokines from blood plasma without introducing any other substances into the blood. The proposed research is expected to provide a tool for better understanding of the fundamental mechanisms governing the adsorption of cytokines by carbon materials. The use of the results of this study in medicine may save the lives of people suffering from autoimmune diseases, severe sepsis, and multiple organ failure. This program will facilitate an interdisciplinary international cooperation between the research groups working on nanoporous carbons in Philadelphia (U.S.) and Brighton (U.K.). Exchange with the group of Professor S. Mikhalovsky, University of Brighton, will allow graduate and undergraduate students from Drexel University to obtain international experience. TECHNICAL DETAILS: The goal of this research is to investigate the effect of pore size, pore shape, particle size, and surface termination of carbide-derived carbons (CDC) on adsorption of cytokines and other proteins. In the CDC process, the metal is extracted from a binary or ternary carbide or carbonitride ceramic by halogens. Therefore, the structure of the carbon can be templated by the carbide structure, with an opportunity for further tuning by controlling the temperature and composition of the environment. Preliminary testing at the University of Brighton has demonstrated that CDC samples significantly outperform the best commercial carbons in the efficiency of protein adsorption. This important breakthrough warrants conducting further studies immediately to explore if a truly transformational approach to sepsis can be carried out. Experimental studies will be performed on cytokine (interleukins and TNF-alpha) adsorption kinetics as a function of the pore size (5-50 nm) by using CDC produced from different precursors. The effects of surface functional groups on the interaction of proteins with the carbon will be experimentally investigated. The PI will determine the conditions for selective adsorption of specific proteins and develop materials with the surface termination and pore size tuned to maximize adsorption capacity and kinetics of adsorption for selected proteins.
非技术描述:严重脓毒症每天杀死的人数与肺癌或乳腺癌相同。 由于脓毒症情况下的炎症反应是由细胞因子驱动的,因此从血液中去除它们会控制驱动脓毒症的不受调节的促炎和抗炎过程。与透析和过滤不同,更不用说基于药物的治疗,吸附可以从血浆中去除细胞因子,而不会将任何其他物质引入血液中。该研究有望为更好地理解碳材料吸附细胞因子的基本机制提供工具。这项研究的结果在医学上的使用可能会挽救患有自身免疫性疾病,严重败血症和多器官衰竭的人的生命。 该计划将促进费城(美国)纳米多孔碳研究小组之间的跨学科国际合作。布莱顿(英国)与S教授小组交流。布莱顿大学的Mikhalovsky将允许德雷克塞尔大学的研究生和本科生获得国际经验。技术规格:本研究的目的是研究碳化物衍生碳(CDC)的孔径,孔形状,颗粒大小和表面终止对细胞因子和其他蛋白质吸附的影响。在CDC工艺中,金属通过卤素从二元或三元碳化物或碳氮化物陶瓷中提取。因此,碳的结构可以通过碳化物结构来模板化,并有机会通过控制环境的温度和组成来进一步调整。布莱顿大学的初步测试表明,CDC样品在蛋白质吸附效率方面明显优于最好的商业碳。这一重要的突破值得立即进行进一步的研究,以探索是否可以对脓毒症进行真正的变革性方法。将通过使用由不同前体产生的CDC对作为孔径(5-50 nm)的函数的细胞因子(白介素和TNF-α)吸附动力学进行实验研究。将实验研究表面官能团对蛋白质与碳相互作用的影响。PI将确定选择性吸附特定蛋白质的条件,并开发具有表面终止和孔径调整的材料,以最大限度地提高选定蛋白质的吸附能力和吸附动力学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Yury Gogotsi其他文献
Carbide-derived carbon membrane
- DOI:
10.1016/j.matchemphys.2008.06.006 - 发表时间:
2008-12-01 - 期刊:
- 影响因子:
- 作者:
Elizabeth N. Hoffman;Gleb Yushin;Bogdan G. Wendler;Michel W. Barsoum;Yury Gogotsi - 通讯作者:
Yury Gogotsi
MXene-enabled textile-based energy grid utilizing wireless charging
- DOI:
10.1016/j.mattod.2024.10.008 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:
- 作者:
Alex Inman;Bita Soltan Mohammadlou;Kateryna Shevchuk;James FitzPatrick;Jung Wook Park;Noah Pacik-Nelson;Iryna Roslyk;Eric M. Gallo;Raghav Garg;Flavia Vitale;Andreea Danielescu;Yury Gogotsi - 通讯作者:
Yury Gogotsi
Confined water controls capacitance
密闭水控制电容
- DOI:
10.1038/s41563-021-01155-4 - 发表时间:
2021-11-23 - 期刊:
- 影响因子:38.500
- 作者:
Patrice Simon;Yury Gogotsi - 通讯作者:
Yury Gogotsi
Materials for electrochemical capacitors
电化学电容器的材料
- DOI:
10.1038/nmat2297 - 发表时间:
2008-11-01 - 期刊:
- 影响因子:38.500
- 作者:
Patrice Simon;Yury Gogotsi - 通讯作者:
Yury Gogotsi
Ion Structure Transition Enhances Charging Dynamics in Subnanometer Pores
离子结构转变增强亚纳米孔中的充电动力学
- DOI:
10.1021/acsnano.9b09648 - 发表时间:
2020 - 期刊:
- 影响因子:17.1
- 作者:
Tangming Mo;Sheng Bi;Yuan Zhang;Volker Presser;Xuehang Wang;Yury Gogotsi;Guang Feng - 通讯作者:
Guang Feng
Yury Gogotsi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Yury Gogotsi', 18)}}的其他基金
I-Corps: Highly Conductive and Additive-free Aqueous MXene Inks for Smart Textile Applications
I-Corps:用于智能纺织应用的高导电性、无添加剂水性 MXene 墨水
- 批准号:
2048759 - 财政年份:2021
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
Synthesis and Optoelectronic Properties of Solid Solution MXenes
固溶体MXene的合成及光电性能
- 批准号:
2041050 - 财政年份:2021
- 资助金额:
$ 12.5万 - 项目类别:
Continuing Grant
EAGER: MXene Sorbents for Continuous Renal Replacement Therapy
EAGER:用于连续肾脏替代治疗的 MXene 吸附剂
- 批准号:
2035007 - 财政年份:2020
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
International Collaboration in Chemistry: Ionic Liquid in Confined Environments
化学国际合作:密闭环境中的离子液体
- 批准号:
0924570 - 财政年份:2009
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
IGERT Fellowships in Nanoscale Science and Engineering: The Two-University/One Campus Approach
IGERT 纳米科学与工程奖学金:两所大学/一所校园的方法
- 批准号:
0654313 - 财政年份:2007
- 资助金额:
$ 12.5万 - 项目类别:
Continuing Grant
RET Site: Research Experiences for Teachers in Nanotechnology (RET-Nano) at Drexel University and the University of Pennsylvania
RET 网站:德雷塞尔大学和宾夕法尼亚大学纳米技术教师 (RET-Nano) 的研究经验
- 批准号:
0743111 - 财政年份:2007
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
Manufacturing of Drug Nano-Dispersions and Nano-Particles by Mechanochemical Synthesis
机械化学合成法制备药物纳米分散体和纳米颗粒
- 批准号:
0556082 - 财政年份:2006
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
NIRT: Nanotube-Based Nanofluidic Devices and Fundamental Fluid Studies at the Nanoscale
NIRT:基于纳米管的纳米流体装置和纳米尺度的基础流体研究
- 批准号:
0609062 - 财政年份:2006
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
The RET Program at Drexel and UPenn: Bringing two universities together to empower Philadelphia teachers in the area of nanotechnology
德雷塞尔大学和宾夕法尼亚大学的 RET 项目:将两所大学联合起来,增强费城教师在纳米技术领域的能力
- 批准号:
0402045 - 财政年份:2004
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
IGERT: Nanoscale Engineering and Science: One Campus, Two- University Approach
IGERT:纳米工程与科学:一个校区、两所大学的方法
- 批准号:
0221664 - 财政年份:2002
- 资助金额:
$ 12.5万 - 项目类别:
Continuing Grant
相似海外基金
Multifunctional High Entropy Carbide and Boride (HECARBO) Ceramic Composites: Compositional Space, Novel Synthesis, and Property Tailoring
多功能高熵碳化物和硼化物 (HECARBO) 陶瓷复合材料:成分空间、新颖合成和性能定制
- 批准号:
EP/Y020804/1 - 财政年份:2024
- 资助金额:
$ 12.5万 - 项目类别:
Research Grant
Advancing bioelectronics with silicon carbide on microfluidics
利用碳化硅微流体技术推进生物电子学
- 批准号:
DE240100408 - 财政年份:2024
- 资助金额:
$ 12.5万 - 项目类别:
Discovery Early Career Researcher Award
Synthesis and characterization of polymer-derived Si-based composites with anti-perovskite carbide and nitride
具有反钙钛矿碳化物和氮化物的聚合物衍生硅基复合材料的合成和表征
- 批准号:
23KF0231 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Grant-in-Aid for JSPS Fellows
SBIR Phase I: Silicon Carbide Radio Frequency Switches
SBIR 第一阶段:碳化硅射频开关
- 批准号:
2334387 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
Elucidation of Carrier Transport in Silicon Carbide MOSFETs and Demonstration of Integrated Circuits Operating at High Temperatures
碳化硅 MOSFET 中载流子传输的阐明以及高温下运行的集成电路的演示
- 批准号:
23KJ1387 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Grant-in-Aid for JSPS Fellows
SBIR Phase I: Radiation Tolerant, High-Voltage, Silicon Carbide Devices
SBIR 第一阶段:耐辐射、高压、碳化硅器件
- 批准号:
2304486 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant
High-Density Active Silicon Carbide Power Electronics: Enabling Responsive Power Conversion
高密度活性碳化硅电力电子器件:实现响应式电力转换
- 批准号:
EP/Y000307/1 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Research Grant
Next Generation Silicon-Carbide MOSFETs for Electrification and Renewable Energies
用于电气化和可再生能源的下一代碳化硅 MOSFET
- 批准号:
10072835 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Grant for R&D
Cosmic ray immunity of silicon carbide power electronic devices. Category Microelectronic device technology - Energy
碳化硅电力电子器件的宇宙射线抗扰度。
- 批准号:
2871797 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Studentship
ERI: Additive Manufacturing of Polymer-Matrix Composites with High Concentration of Silicon-Carbide Particles by Novel Digital Light Projection
ERI:通过新型数字光投影增材制造高浓度碳化硅颗粒的聚合物基复合材料
- 批准号:
2301462 - 财政年份:2023
- 资助金额:
$ 12.5万 - 项目类别:
Standard Grant