Mechanism of Enyne Metathesis

该奖项授予纽约州立大学布法罗分校的Steven Diver和Jerome Keister，他们的目标是通过有机化学家和无机化学家的合作，对酶的分解反应机制进行研究。炔复分解反应已成为一种有价值的合成方法，应用于化学的许多领域。共轭二烯是由炔复分解产生的，在有机合成中有广泛的用途，是合成各种重要分子的基石。虽然烯烃的转化反应已经被很好地理解了，但炔的转化反应还不是很清楚，所以我们计划对分子间炔的转化反应进行详细的动力学研究。该研究将使用基于红外光谱的动力学方法和广泛的有机反应物来研究结构如何影响速率。基础的乙烯基卡宾化学将通过卡宾配合物的合成和反应性研究来支持动力学研究。预计这些研究将阐明乙烯基碳烯的反应性质。更广泛的影响。在一个有机和无机化学家参与的协作学习环境中，对这种合成有用的反应进行严格的研究，为本科生和研究生提供了一个极好的跨学科培训机会。从事该项目的研究生将培养成为独立科学家的技能，并学会在研究小组之间的团队中工作。进一步预期，这些研究将使更广泛的烯烃和炔烃底物的炔分解更有效，并将为在许多类型的有机合成中使用炔分解反应提供合理的基础，包括天然产物，药物和精细化学品。

This award to Steven Diver and Jerome Keister of the State University of New York at Buffalo has as its goal the investigation of the reaction mechanism of enyne metathesis in a collaborative effort between an organic and an inorganic chemist. The enyne metathesis reaction has emerged as a valuable synthetic method used in many fields of chemistry. Conjugated dienes produced by enyne metathesis, are broadly useful in organic synthesis and serve as building blocks for the synthesis of a variety of important molecules. Although alkene metathesis is well understood, enyne metathesis is not, so a detailed kinetic study of the intermolecular enyne metathesis is planned. The studies will use an infrared spectroscopic based kinetic method and a broad range of organic reactants to study how structure influences rate. Fundamental vinyl carbene chemistry will be investigated to support the kinetic studies through carbene complex synthesis and reactivity studies. It is anticipated that these studies will illuminate the reactive nature of vinyl carbenes. Broader Impacts. Rigorous study of this synthetically useful reaction in a collaborative learning environment, involving an organic and an inorganic chemist, offers an excellent interdisciplinary training opportunity for undergraduate and graduate students. Graduate students working on this project will develop the skills to become independent scientists and learn to work in a team among research groups. It is further anticipated that these studies will make enyne metathesis more efficient for a broader range of alkene and alkyne substrates and will develop a rational basis for using the enyne metathesis reaction in many types of organic syntheses including natural products, pharmaceuticals and fine chemicals.