Ruthenium Vinyl Carbene Reactivity

钌乙烯基卡宾反应性

• 批准号: 1012839
• 负责人: Steven Diver
• 金额: $ 46.8万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1012839&HistoricalAwards=false
• 关键词: Ruthenium; Vinyl; Carbene; Reactivity

The Chemical Catalysis Program supports Professors Steven T. Diver and Jerome B. Keister at the State University of New York (SUNY) at Buffalo who have proposed a research program that will focus on studying enyne metathesis, which offers a direct catalytic synthesis of 1,3-dienes from simple unsaturated reactants. There is a substantial lack of information concerning the mechanism of the reaction and the structural parameters in the alkyne and alkene substrates affecting the outcome of the process. The proposal is focused on understanding the intimate steps of the catalytic cycle and the role of each reagent in influencing the reaction rate. The study is intended to be systematic and carried out under a variety of conditions. The study is based on chemical kinetics that will be performed using in-situ Fourier Transform Infrared Spectroscopy (FT-IR), thus allowing the continuous monitoring of the reaction. Special attention will be given to the functional group tolerance in the substrates, a point that is not well understood due to the lack of a systematic study of this reaction. Understanding this reaction and the development of more practical enyne metathesis may lead to industrial applications especially in fine chemical synthesis in the pharmaceutical industry.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Dr. Steven T. Diver and Jerome B. Keister will perform detailed mechanistic studies that are likely to shed light on fundamental pathways that could lead to the design of more robust and efficient catalysts. A better understanding of enyne metathesis could provide reagents for chemical biology that may help in the study of human diseases and lead to new drugs and more cost effective syntheses. This contribution to the lower the cost of pharmaceuticals could help alleviate the high cost of healthcare on the US economy. The research will involve students at all levels and provide a collaborative learning environment. The PIs will continue to involve high school students, females and persons from underrepresented groups in their research.

化学催化计划支持教授史蒂芬T。戴弗和杰罗姆B。位于布法罗的纽约州立大学（SUNY）的Keister提出了一项研究计划，该计划将重点研究烯炔复分解反应，该反应提供了从简单的不饱和反应物直接催化合成1，3-二烯。有一个实质性的信息缺乏有关的反应机制和结构参数的炔和烯烃底物影响的结果的过程。该提案的重点是了解催化循环的密切步骤和影响反应速率的每种试剂的作用。这项研究是系统的，在各种条件下进行。该研究基于化学动力学，将使用原位傅里叶变换红外光谱（FT-IR）进行，从而可以连续监测反应。特别注意将给予在基板的功能基团的宽容，这一点是没有很好地理解，由于缺乏一个系统的研究，这种反应。了解这一反应和更实际的烯炔复分解的发展可能会导致工业应用，特别是在制药工业的精细化学合成中。戴弗和杰罗姆B。Keister将进行详细的机理研究，这些研究可能会揭示可能导致设计更强大和更有效的催化剂的基本途径。更好地了解烯炔复分解可以为化学生物学提供试剂，这可能有助于人类疾病的研究，并导致新药和更具成本效益的合成。这对降低药品成本的贡献可能有助于减轻美国经济的高医疗成本。该研究将涉及各级学生，并提供一个协作学习环境。研究所将继续让高中生、女性和代表性不足群体的人参与其研究。