Ruthenium Vinyl Carbene Reactivity

化学催化计划支持纽约州立大学布法罗分校的Steven T.Diver和Jerome B.Keister教授提出的一项研究计划，该计划将重点研究烯炔的歧化反应，该计划提供了从简单的不饱和反应物直接催化合成1，3-二烯的方法。关于反应机理和影响该过程结果的炔烃和烯烃底物中的结构参数，信息非常缺乏。该提案的重点是了解催化循环的密切步骤以及每种试剂在影响反应速度方面的作用。这项研究打算是系统性的，并在各种条件下进行。这项研究基于化学动力学，将使用原位傅里叶变换红外光谱(FT-IR)进行，从而能够连续监测反应。将特别注意底物中的官能团耐受性，由于缺乏对该反应的系统研究，这一点还没有得到很好的理解。了解这一反应和更实用的烯炔歧化反应的发展可能会导致工业应用，特别是在制药工业的精细化学合成中。在国家科学基金会化学部化学催化计划的支持下，Steven T.Diver博士和Jerome B.Keister博士将进行详细的机理研究，可能有助于揭示可能导致更强大和高效催化剂设计的基本途径。更好地理解烯炔的歧化反应可以为化学生物学提供试剂，这可能有助于人类疾病的研究，并导致新药和更具成本效益的合成。这种对降低药品成本的贡献，可能有助于缓解医疗保健对美国经济的高昂成本。这项研究将涉及所有级别的学生，并提供一个协作的学习环境。PIs将继续让高中生、女性和来自代表性不足群体的人参与他们的研究。

The Chemical Catalysis Program supports Professors Steven T. Diver and Jerome B. Keister at the State University of New York (SUNY) at Buffalo who have proposed a research program that will focus on studying enyne metathesis, which offers a direct catalytic synthesis of 1,3-dienes from simple unsaturated reactants. There is a substantial lack of information concerning the mechanism of the reaction and the structural parameters in the alkyne and alkene substrates affecting the outcome of the process. The proposal is focused on understanding the intimate steps of the catalytic cycle and the role of each reagent in influencing the reaction rate. The study is intended to be systematic and carried out under a variety of conditions. The study is based on chemical kinetics that will be performed using in-situ Fourier Transform Infrared Spectroscopy (FT-IR), thus allowing the continuous monitoring of the reaction. Special attention will be given to the functional group tolerance in the substrates, a point that is not well understood due to the lack of a systematic study of this reaction. Understanding this reaction and the development of more practical enyne metathesis may lead to industrial applications especially in fine chemical synthesis in the pharmaceutical industry.With the support of the Chemical Catalysis Program in the Chemistry Division at the National Science Foundation, Dr. Steven T. Diver and Jerome B. Keister will perform detailed mechanistic studies that are likely to shed light on fundamental pathways that could lead to the design of more robust and efficient catalysts. A better understanding of enyne metathesis could provide reagents for chemical biology that may help in the study of human diseases and lead to new drugs and more cost effective syntheses. This contribution to the lower the cost of pharmaceuticals could help alleviate the high cost of healthcare on the US economy. The research will involve students at all levels and provide a collaborative learning environment. The PIs will continue to involve high school students, females and persons from underrepresented groups in their research.