PFI-TT: New metal scavengers for metal recycling and sustainable chemical manufacturing

PFI-TT：用于金属回收和可持续化学制造的新型金属清除剂

• 批准号: 2329818
• 负责人: Steven Diver
• 金额: $ 43.39万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2329818&HistoricalAwards=false
• 关键词: PFI; TT; New; metal; scavengers

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project includes sustainable chemical synthesis and more cost-effective chemical manufacturing. Recovery of metals will have a direct impact in the pharmaceutical sector by assisting compliance with regulatory requirements related to trace metals in pharmaceutical ingredients. This new approach will help lower the cost of the drug development process. Furthermore, entrepreneurship training for the next generation of leaders in commercialization of technologies is proposed, through the grant activity and a formal training program. This broader impact will enhance human resources for future technology transfer by helping chemistry graduate students envision an entrepreneurial career. Lastly, metals play a vital role in the US economy and in defense. The declaration of certain essential metals needed by the federal government is expected to increase the demand for sustainable practices in the recovery, recycling, and reuse of these metals. Since isocyanides are strong binding ligands, they have the potential to affect other markets such as commodity chemicals and metal recycling, where current scavengers have limited impact due to their ineffectiveness and high cost. This project has the potential to impact a larger market segment of the economy, and result in a more efficient and sustainable chemical manufacturing.The proposed project develops isocyanide-based scavengers for sustainable chemical synthesis. Scavengers allow precious metals to be recovered and recycled. Metals are widely used in the chemical industry as catalysts for cost effective chemical production. In this proposal, five new solid supported isocyanide scavengers will be produced in large scale and sold in the market, with emphasis on the pharmaceutical industry. A streamlined two step synthesis was validated and allowed the estimation of a significantly reduced cost on production scale. This cost decrease is projected to allow the new scavengers to be cost-competitive with existing technology, stimulating market uptake. In addition to the polystyrene-based and silica gel-based isocyanides, a cartridge will be developed to aid in the rapid screening of scavengers, facilitating comparisons by a validated practice. Preliminary data show that the currently developed gel-supported isocyanide proposed in this project was superior to existing technologies, suggesting that this technology will be highly competitive in the marketplace.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这一创新-技术转化伙伴关系项目更广泛的影响/商业潜力包括可持续的化学合成和更具成本效益的化学制造。金属回收将对制药部门产生直接影响，因为它有助于遵守与药物成分中微量金属有关的监管要求。这种新方法将有助于降低药物开发过程的成本。此外，还提议通过赠款活动和正式培训方案，对技术商业化的下一代领导人进行创业培训。这种更广泛的影响将通过帮助化学研究生设想创业生涯来增强未来技术转让的人力资源。最后，金属在美国经济和国防中发挥着至关重要的作用。联邦政府需要的某些基本金属的声明预计将增加对这些金属的回收、再循环和再利用的可持续做法的需求。由于异氰化物是强结合配体，它们有可能影响其他市场，如商品化学品和金属回收，而目前的清除剂由于效率低和成本高，影响有限。该项目有可能影响更大的经济细分市场，并导致更有效和可持续的化学品制造。拟议的项目开发用于可持续化学合成的异氰化物清除剂。清除剂允许贵金属被回收和再循环。金属在化学工业中广泛用作催化剂，用于成本有效的化学生产。在该提案中，将大规模生产五种新型固体负载异氰根清除剂并在市场上销售，重点是制药行业。验证了简化的两步合成，并允许在生产规模上估计显著降低的成本。预计这种成本的降低将使新的清除剂与现有技术相比具有成本竞争力，从而刺激市场的吸收。除了聚苯乙烯基和硅胶基异氰化物外，还将开发一种滤筒，以帮助快速筛选清除剂，便于通过经验证的做法进行比较。初步数据显示，目前开发的凝胶支持异氰化物在这个项目中提出的是上级现有的技术，这表明，这项技术将在市场上具有很强的竞争力。这个奖项反映了NSF的法定使命，并已被认为是值得通过评估使用基金会的智力价值和更广泛的影响审查标准的支持。