PFI-TT: New metal scavengers for metal recycling and sustainable chemical manufacturing

创新-技术转化伙伴关系（PFI-TT）项目的更广泛影响/商业潜力包括可持续的化学合成和更具成本效益的化学制造。金属的回收将对制药部门产生直接影响，有助于遵守与药物成分中微量金属有关的监管要求。这种新方法将有助于降低药物开发过程的成本。此外，还提议通过赠款活动和正式培训方案，对技术商业化方面的下一代领导人进行创业培训。这种更广泛的影响将通过帮助化学研究生设想创业生涯来增强未来技术转让的人力资源。最后，金属在美国经济和国防中发挥着至关重要的作用。联邦政府所需的某些必需金属的声明预计将增加对这些金属的回收、再循环和再利用的可持续实践的需求。由于异氰酸酯是强结合配体，它们有可能影响其他市场，如商品化学品和金属回收，目前的清除剂由于其无效和高成本而影响有限。该项目有可能影响更大的经济细分市场，并导致更高效和可持续的化学品制造。拟议的项目开发基于异氰化物的可持续化学合成清除剂。拾荒者可以回收和循环利用贵重金属。金属在化学工业中被广泛用作催化剂，以实现成本效益高的化学生产。在本方案中，五种新型固体负载异氰化物清除剂将大规模生产并在市场上销售，重点是制药行业。验证了一种简化的两步合成方法，并允许在生产规模上显著降低成本的估计。预计这一成本的降低将使新的清除剂与现有技术相比具有成本竞争力，从而刺激市场的吸收。除了聚苯乙烯基和硅胶基异氰化物外，还将开发一种药筒，以帮助快速筛选清除剂，通过经过验证的实践进行比较。初步数据表明，该项目目前开发的凝胶负载异氰化物优于现有技术，表明该技术在市场上具有很强的竞争力。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project includes sustainable chemical synthesis and more cost-effective chemical manufacturing. Recovery of metals will have a direct impact in the pharmaceutical sector by assisting compliance with regulatory requirements related to trace metals in pharmaceutical ingredients. This new approach will help lower the cost of the drug development process. Furthermore, entrepreneurship training for the next generation of leaders in commercialization of technologies is proposed, through the grant activity and a formal training program. This broader impact will enhance human resources for future technology transfer by helping chemistry graduate students envision an entrepreneurial career. Lastly, metals play a vital role in the US economy and in defense. The declaration of certain essential metals needed by the federal government is expected to increase the demand for sustainable practices in the recovery, recycling, and reuse of these metals. Since isocyanides are strong binding ligands, they have the potential to affect other markets such as commodity chemicals and metal recycling, where current scavengers have limited impact due to their ineffectiveness and high cost. This project has the potential to impact a larger market segment of the economy, and result in a more efficient and sustainable chemical manufacturing.The proposed project develops isocyanide-based scavengers for sustainable chemical synthesis. Scavengers allow precious metals to be recovered and recycled. Metals are widely used in the chemical industry as catalysts for cost effective chemical production. In this proposal, five new solid supported isocyanide scavengers will be produced in large scale and sold in the market, with emphasis on the pharmaceutical industry. A streamlined two step synthesis was validated and allowed the estimation of a significantly reduced cost on production scale. This cost decrease is projected to allow the new scavengers to be cost-competitive with existing technology, stimulating market uptake. In addition to the polystyrene-based and silica gel-based isocyanides, a cartridge will be developed to aid in the rapid screening of scavengers, facilitating comparisons by a validated practice. Preliminary data show that the currently developed gel-supported isocyanide proposed in this project was superior to existing technologies, suggesting that this technology will be highly competitive in the marketplace.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.