PFI-TT: New metal scavengers for metal recycling and sustainable chemical manufacturing

这一创新-技术转化伙伴关系(PFI-TT)项目的广泛影响/商业潜力包括可持续的化学合成和更具成本效益的化学制造。回收金属将有助于遵守与药物成分中痕量金属有关的监管要求，从而对制药部门产生直接影响。这一新方法将有助于降低药物开发过程的成本。此外，还建议通过赠款活动和正式培训方案，为技术商业化方面的下一代领导人提供创业培训。这一更广泛的影响将通过帮助化学研究生展望创业生涯，为未来的技术转让加强人力资源。最后，金属在美国经济和国防中扮演着至关重要的角色。联邦政府需要的某些基本金属的申报预计将增加对这些金属的回收、循环和再利用方面的可持续做法的需求。由于异氰化物是强结合配体，它们有可能影响其他市场，如商品化学品和金属回收，目前的清除剂由于效率低和成本高，影响有限。这个项目有可能影响更大的经济市场，并导致更有效和更可持续的化学制造。拟议的项目开发基于异氰化物的清除剂，用于可持续的化学合成。拾荒者允许回收和循环使用贵金属。金属在化学工业中被广泛用作成本效益高的化学品生产的催化剂。在这项提案中，将大规模生产并在市场上销售5种新型固体负载型异氰酸酯清除剂，重点放在医药行业。简化的两步合成得到了验证，并且可以在生产规模上估计显著降低的成本。这种成本的降低预计将使新的拾荒者能够在成本上与现有技术竞争，从而刺激市场吸收。除了聚苯乙烯基异氰化物和硅胶基异氰化物外，还将开发一种色谱柱，以帮助快速筛选清道夫，便于通过验证的做法进行比较。初步数据显示，该项目目前开发的凝胶支撑异氰化物优于现有技术，表明该技术在市场上将具有很强的竞争力。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project includes sustainable chemical synthesis and more cost-effective chemical manufacturing. Recovery of metals will have a direct impact in the pharmaceutical sector by assisting compliance with regulatory requirements related to trace metals in pharmaceutical ingredients. This new approach will help lower the cost of the drug development process. Furthermore, entrepreneurship training for the next generation of leaders in commercialization of technologies is proposed, through the grant activity and a formal training program. This broader impact will enhance human resources for future technology transfer by helping chemistry graduate students envision an entrepreneurial career. Lastly, metals play a vital role in the US economy and in defense. The declaration of certain essential metals needed by the federal government is expected to increase the demand for sustainable practices in the recovery, recycling, and reuse of these metals. Since isocyanides are strong binding ligands, they have the potential to affect other markets such as commodity chemicals and metal recycling, where current scavengers have limited impact due to their ineffectiveness and high cost. This project has the potential to impact a larger market segment of the economy, and result in a more efficient and sustainable chemical manufacturing.The proposed project develops isocyanide-based scavengers for sustainable chemical synthesis. Scavengers allow precious metals to be recovered and recycled. Metals are widely used in the chemical industry as catalysts for cost effective chemical production. In this proposal, five new solid supported isocyanide scavengers will be produced in large scale and sold in the market, with emphasis on the pharmaceutical industry. A streamlined two step synthesis was validated and allowed the estimation of a significantly reduced cost on production scale. This cost decrease is projected to allow the new scavengers to be cost-competitive with existing technology, stimulating market uptake. In addition to the polystyrene-based and silica gel-based isocyanides, a cartridge will be developed to aid in the rapid screening of scavengers, facilitating comparisons by a validated practice. Preliminary data show that the currently developed gel-supported isocyanide proposed in this project was superior to existing technologies, suggesting that this technology will be highly competitive in the marketplace.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.