MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer for Research and Training

MRI：采购 500 MHz 核磁共振 (NMR) 波谱仪用于研究和培训

• 批准号: 2018160
• 负责人: Steven Diver
• 金额: $ 45.43万
• 依托单位: SUNY at Buffalo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018160&HistoricalAwards=false
• 关键词: MRI; Acquisition; 500; MHz; Nuclear

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The State University of New York (SUNY) at Buffalo is acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with an automatic sample changer to support Professor Steven Diver and colleagues: Timothy Cook, Bing Gong, Janet Morrow and Javid Rzavev. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically-relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. NMR is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is important to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate and graduate students in chemistry and biochemistry at this institution and nearby universities in Western New York such as Canisius College, D’Youville College, Hauptman-Woodward Medical Research Institute and Medaille College.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. This instrument acquisition impacts studies of chalcogen-containing cationic dyes used in photocatalysis. The instrumentation is used in investigations of small molecules activation using coordination-driven self-assembly and nanoporous organic structures based on folding and assembly. In addition, the spectrometer provides information to aid the design, preparation, and studies of size-selective macrocycle catalysts of importance in manufacturing. The instrument is also used to explore the use of iron(III) coordination complexes and magnetic resonance imaging (MRI) contrast agents and guides the design of polymer assembly with defined molecular architectures.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。位于布法罗的纽约州立大学正在购买一台配备自动进样器的500 MHz核磁共振（NMR）光谱仪，以支持Steven Diver教授及其同事：Timothy Cook、Bing Gong、Janet Morrow和Javid Rzavev。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及允许研究生物相关物种。一般来说，NMR光谱是化学家用来阐明分子结构的最有力的工具之一。NMR用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪非常重要。该仪器是该机构和附近纽约西部大学（如Canisius学院、D 'Youville学院、Hauptman-Woodward医学研究所和Medaille学院）化学和生物化学本科生和研究生教学、研究和研究培训的一个组成部分。授予NMR光谱仪旨在加强各级研究和教育。该仪器的获得影响了用于染料的含硫族阳离子染料的研究。该仪器用于研究小分子活化，使用协调驱动的自组装和基于折叠和组装的纳米多孔有机结构。此外，光谱仪提供的信息，以帮助设计，制备和研究的尺寸选择性大环催化剂的重要性，在制造。该仪器还用于探索铁（III）配位络合物和磁共振成像（MRI）造影剂的使用，并指导具有定义的分子结构的聚合物组件的设计。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Co( ii ) complexes of tetraazamacrocycles appended with amide or hydroxypropyl groups as paraCEST agents

带有酰胺或羟丙基的四氮杂大环Co(ii)配合物作为对位CEST试剂

• DOI: 10.1039/d3dt01572f
• 发表时间: 2023
• 期刊: Dalton Transactions
• 影响因子: 4
• 作者: Raymond, Jaclyn J.;Abozeid, Samira M.;Sokolow, Gregory E.;Bond, Christopher J.;Yap, Constance E.;Nazarenko, Alexander Y.;Morrow, Janet R.
• 通讯作者: Morrow, Janet R.

Liposomal MRI probes containing encapsulated or amphiphilic Fe(III) coordination complexes

含有封装或两亲性 Fe(III) 配位络合物的脂质体 MRI 探针

• DOI: 10.1039/d3bm00029j
• 发表时间: 2023
• 期刊: Biomaterials Science
• 影响因子: 6.6
• 作者: Chowdhury, Md Saiful;Kras, Elizabeth A.;Turowski, Steven G.;Spernyak, Joseph A.;Morrow, Janet R.
• 通讯作者: Morrow, Janet R.

Shining Light on the Solution- and Excited-State Dynamics of Chalcogenopyrylium Polymethine Dyes

• DOI: 10.1021/acs.organomet.2c00263
• 发表时间: 2022-08-09
• 期刊: ORGANOMETALLICS
• 影响因子: 2.8
• 作者: Rosch，Lauren E.;Crawley，Matthew R.;Cook，Timothy R.
• 通讯作者: Cook，Timothy R.