Oxidative Methods for C-C and C-N Bond Formation

该项目将继续开发通过容易的氧化反应形成C-C和C-N键的方法。虽然苯酚衍生物的二聚反应是公认的过程，但通过氧化二聚反应合成手性联芳烃的催化不对称方法的研究进展甚微。将开展进一步阐明这一复杂催化循环的机理的研究。将对具有过渡金属氧化剂的配体进行组合类型筛选，以确定新的有用催化剂。还将对新的氧化反应进行假设驱动的研究。通过这一奖项，有机和高分子化学项目和多学科活动办公室支持宾夕法尼亚大学化学系玛丽萨·C·科兹洛夫斯基教授的研究。科兹洛夫斯基教授的研究工作围绕着C-C和C-N键形成的简易氧化方法的开发。这种化学将有助于环境友好的化学合成方法，因为氧气被用作终端氧化剂。该方法的成功开发将对制药和农业中的合成产生影响。

This project will continue work on the development of methods for the formation of C-C and C-N bonds by facile oxidative reactions. While dimerizations of phenol derivatives are well-recognized processes, little progress has been made in the development of catalytic asymmetric methods for the formation of chiral biaryls via oxidative dimerization. Studies to further elucidate the mechanism of this complex catalytic cycle will be undertaken. Combinatorial type screening of ligands with transition metal oxidants will be carried out to identify new useful catalysts. Hypothesis driven studies of new oxidative reactions will be also performed. With this award, the Organic and Macromolecular Chemistry Program and the Office of Multidisciplinary Activities are supporting the research of Professor Marisa C. Kozlowski of the Department of Chemistry at University of Pennsylvania. Professor Kozlowski's research efforts revolve around the development of facile oxidative methods for the formation of C-C and C-N bonds. Such chemistry will contribute to environmentally benign methods for chemical synthesis as oxygen is used as the terminal oxidizing agent. Successful development of the methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.