Acquisition of a Shared Mass Spectrometer for Research, Education, and Training

该奖项是对购买具有ESI、APCI、APPI、MALDI、MS/MS和精确质量能力的高分辨率质谱仪的奖励。该仪器将为八个不同实验室的广泛研究项目提供急需的分析支持。他们的研究项目主要集中在化学生物学、生物化学和合成有机化学领域，包括以下内容：(1)分析非核糖体天然产物生物合成的化学工具，(2)揭示异前列腺素磷脂的细胞相互作用，(3)作为蛋白质和DNA损伤模型的多肽插入物，(4)序列特异性DNA靶向，(5)利用质谱学研究膜/蛋白质相互作用和古代谢物，以及(6)不对称合成的仿生催化剂。新仪器将加强对研究生、本科生和博士后的教育和培训。这八个研究实验室总共由84名研究生、19名博士后和25名本科生组成，其中绝大多数将定期使用所要求的质谱计。质谱学实验将被纳入化学和生物化学专业的本科课程。为了教育和吸引尽可能多的本科生学习现代质谱学的理论和实践，还将为附近本科院校的学生提供样本。

This award is for the acquisition of a high resolution mass spectrometer with ESI, APCI, APPI, MALDI, MS/MS, and exact-mass capabilities. The instrument will provide much needed analytical support for a broad range of research programs in eight different laboratories. Their research programs are concentrated primarily in the areas of chemical biology, biochemistry, and synthetic organic chemistry and include the followiing: (1) Chemical Tools to Dissect Nonribosomal Peptide Natural Product Biosynthesis, (2) Uncovering the Cellular Interactions of Isoprostanyl Phospholipids, (3) Peptidointercalator Conjugates as Models of Protein and DNA Damage, (4) Sequence-specific Targeting of DNA, (5) Use of Mass Spectrometry in Studying Membrane/Protein Interactions and Archaeal Metabolomes, and (6) Biomimetic Catalysts for Asymmetric Synthesis. The new instrument will enhance the education and training of graduate students, undergraduates, and postdocs. Collectively, the eight research laboratories comprise a group of 84 graduate students, 19 postdocs, and 25 undergraduate research students, the great majority of whom will be users of the requested mass spectrometer on a regular basis. Mass spectrometry experiments will be incorporated into the undergraduate curricula for chemistry and biochemistry majors. To educate and engage as many undergraduate students as possible in the theory and practice of modern mass spectrometry, samples will be run also for students at nearby undergraduate institutions.