SGER: Aquatic Nanotoxicology of Nanomaterials and Their Biomolecular Derivatives

[06:30823]纳米材料及其广泛的影响正在迅速地重塑我们的科学和技术的面貌。这项探索性研究旨在解决理解生物系统和环境中无生命纳米材料的关键需求。本研究旨在研究单壁碳纳米管（SWNTs）（一类主要的纳米材料）与天然溶血磷脂之间的生物物理相互作用，并研究脂溶碳纳米管在细胞和整个动物体内的毒性。这些目标将由一个具有创造力和生产力的协同研究小组进行调查，他们的专业知识涵盖纳米技术、生物物理学、生物学、工程学和环境毒理学等领域。

0630823KeNanomaterials and their broad implications are rapidly reshaping the landscape of our science and technology. This proposed exploratory research is to address the crucial need of understanding lifeless nanomaterials in biological systems and in the environment. Three objectives are designed to examine the biophysical interactions of single-walled carbon nanotubes (SWNTs), a major class of nanomaterials, and naturally occurring lysophospholipids, and to investigate the toxicity of lipid-solubilized SWNTs in cells and in whole animals. These objectives will be investigated by a synergetic team of researchers who have track records of creativity and productivity and whose expertise encompasses the fields of nanotechnology, biophysics, biology, engineering, and environmental toxicology.