MRI: Acquisition of an EPR Spectrometer

犹他州立大学化学和生物化学系将获得一个没有磁铁和电源的EPR光谱仪，该奖项来自主要研究仪器项目（MRI）。该仪器将用于多个研究项目，包括：(1)氮酶的机制研究，(2)脂肪酰环氧化物和酮羧基化关键酶的金属中心和CoM结合决定因素的表征，(3)乙草醛酶II酶活性位点双核金属中心的模型配合物，以及(4)白内障超声乳化术中自由基的形成。电子顺磁共振（EPR）谱仪产生分子和分子电子结构的信息。它也可以用来获得自由基的寿命信息，自由基是肿瘤生长和/或各种化学反应的起始所必需的短命物种。这些研究将提供有关生物系统中反应性的化学基础的宝贵信息

With this award from the Major Research Instrumentation program (MRI), the Department of Chemistry and Biochemistry at Utah State University will acquire an EPR spectrometer without the magnet and power supply. This instrument will be used in several research projects including (1) mechanistic studies of nitrogenase, (2) characterization of metal centers and CoM binding determinant in key enzymes of aliphatic epoxide and ketone carboxylation, (3) model complexes for active site binuclear metal centers in glyoxalase II enzymes, and (4) free radical formation during cataract phacoemulsification.An electron paramagnetic resonance (EPR) spectrometer yields information on the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals, short-lived species that are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will yield valuable information the chemical basis of reactivity in biological systems