Improving the Understanding of the Properties and Retention Behavior of Chemically Bonded Stationary Phases Employing Spectroscopic and Chromatographic Characterization Techniques

化学系的分析和表面化学计划支持圣何塞州立大学的约瑟夫·佩塞克教授和图宾根大学的克劳斯·阿尔伯特教授的合作研究计划。该奖项与由德国科学基金会(DFG)通过NSF和DFG之间的一个联合项目资助的合作奖项相协调，该项目为美国和德国研究人员之间的合作项目提供资金。合作的重点是更好地了解如何使用基于二氧化硅的材料根据分子的化学和物理性质分离分子。分离介质将主要通过核磁共振光谱进行研究，这是一种可以测量各种类型的化合物如何与二氧化硅表面相互作用的技术。二氧化硅颗粒表面与混合物中存在的分子之间的不同程度的相互作用导致这些化合物的分离，并提供了一种分析手段。二氧化硅表面的改性可用于控制各种类型混合物的分离。了解这些过程将导致开发更好的分离材料，用于分析药物、临床、环境和生物样品中遇到的复杂混合物。合作的一个关键组成部分将是学生的参与，他们将有机会参与一个多学科的国际研究项目。两个实验室之间的学生交流将增强参与者的合作研究体验。该奖项由美国国家科学基金会国际科学与工程办公室共同资助。

The Analytical and Surface Chemistry Program in the Division of Chemistry supports the collaborative research program of Prof. Joseph Pesek at San Jose State University and Prof. Klaus Albert at the University of Tuebingen. This award coordinates with a collaborative award funded by the Deutsche Forschungsgemeinschaft (DFG) through a joint program between the NSF and DFG that funds collaborative projects between US and German investigators.The focus of the collaboration is to better understand how molecules are separated based on their chemical and physical properties using materials based on silica. The separation media will be studied mainly by nuclear magnetic resonance spectroscopy, a technique that can measure how various types of compounds interact with the silica surface. Varying degrees of interaction between the surface of silica particles and the molecules present in a mixture result in separation of these compounds and provide a means of analysis. Modification of silica surfaces can be used for controlling the separation of various types of mixtures. Understanding these processes will lead to the development of better separation materials to be used in the analysis of complex mixtures encountered in pharmaceutical, clinical, environmental and biological samples. A key component in the collaboration will be the involvement of students who will have an opportunity to work in a multi-disciplinary international research project. Exchanges of students between the two laboratories will enhance the collaborative research experiences of the participants. The award is co-funded by the Office of International Science and Engineering at NSF.