Massively Parallel Manufacturing of Nanoscale Wires with Magnetic and Metallic Properties

这项资助的所有具体目标都是为了验证制造尺寸为1-10 nm纳米线的制造策略。 它们的制造是重要的，因为现代技术的进步与我们制造由单分子组分组成的装置的能力直接相关。 目前的方法产量低，依赖于缓慢和串行协议，只适用于研究实验室。 在这项资助中，我们计划利用一种长的生物分子DNA作为制造磁性纳米线的支架。 这种导线将被放置在光电重要表面上，并用于构建几纳米量级的纳米级间隙。 缺口将使用内切核酸酶制造，所述内切核酸酶是能够以位点特异性方式切割DNA的酶，尽管表面上存在磁性材料。 间隙B对于真实的器件应用是有用的，因为制造工艺将与标准半导体技术兼容。 该方法是大规模并行的，可以产生具有可变尺寸的线和间隙，它是低成本的，因为不利用设备并且仅需要少量的生物材料。这些研究将有助于了解如何解决纳米制造中的一些主要挑战。更具体地说，通过生物启发方法制造纳米级组件的研究策略满足了将纳米元件制造和组装成设备和系统的需求。 此外，我们提出的方法来验证提供了一个新的路线，以满足与精度控制的位置和注册的挑战。 这项工作有两个主要主题：i）了解如何使用称为限制酶的生物分子在电子重要表面上制造纳米级间隙; ii）验证分析框架以测试生成的纳米级间隙的特性。 从（生物）传感器到电子设备的各种领域都可以从我们提出开发的纳米制造过程的潜在产品中受益。 从事该项目的本科生也将参与一个社区项目，纳米制造演示，旨在向初中和高中学生介绍纳米制造的概念。 参与这项研究的研究生将每年参加一次纳米制造博览会，以帮助他们学习向更广泛的受众传达他们的工作成果。 总的来说，学生在实验室外所做的工作对公众关于纳米科学和工程研究与开发的影响的教育非常有帮助。

All the specific aims of this grant target the need to validate manufacturing strategies to fabricate nanowires with dimensions of 1-10 nm. Their fabrication is important since the advancement of modern technologies is directly related to our ability to manufacture devices composed of single molecular components. Current methodologies have low yields and rely on slow and serial protocols that are only applicable to research laboratories. In this grant we plan to utilize a long biomolecule, DNA, as a scaffold for the fabrication of magnetic nanowires. Such wires will be placed on optoelectronically important surfaces and used for the construction of nanoscale gaps on the order of a few nanometers. The gaps will be manufactured using endonucleases which are enzymes capable of cutting the DNA in a site-specific fashion despite the presence of magnetic materials on the surface. The gaps will b be useful for real device applications because the fabrication process will be compatible with standard semiconductor technology. This methodology is a massively parallel, can yield wires and gaps with variable sizes, it is low cost since one utilizes no equipment and only small amounts of biological materials are needed. These studies will contribute to the understanding of how to address some of the major challenges in nanomanufacturing. More specifically the research strategy to fabricate nanoscale components via bio-inspired approaches fulfils the need to make and assemble nano-elements into devices and systems. Furthermore, the methodology we propose to validate offers a new route to meet challenges tied to precision control over placement and registration. The work has two main themes: i) understanding how to manufacture nanoscale gaps on electronically important surfaces using biomolecules called restriction enzymes; and ii) validation of an analytical framework to test the properties of the generated nanoscale gaps. A variety of fields ranging from (bio)sensors to electronic devices can benefit from the potential products of the nanomanufacturing processes we propose to develop. Undergraduate students who work on this project will also be involved in a community project, the Nanomanufacturing Demos, designed to introduce concepts of nanomanucturing to middle and high school students. Graduate students who participate in this research will be involved in a Nanomanufacturing Expo every year to help them learn to communicate to a broader audience the outcomes of their work. Overall, the work the students will do outside the laboratory can be exceptionally helpful to the education of the general public with respect to the impacts of nanoscience and engineering research and development.