EMSW21-RTG: Complex Biological Systems Across Multiple Space and Time Scales

这个研究培训小组（RTG）将专注于培训新一代科学家(1)开发分析和计算算法，以解决生物学中出现的复杂时空问题；(2)将这些方法和其他方法应用于神经科学和炎症中出现的问题。特别是，在计算方面，该项目将开发耦合生物过程的有效离散化，迭代求解器和耦合/解耦策略。在神经科学应用方面，研究人员将在传播波和持续活动模式、同步性和节律性、噪声和突触可塑性方面获得新的成果。在炎症应用方面，研究项目涉及流感感染、炎症和败血症的免疫反应，以及坏死性小肠结肠炎和伤口愈合的模型。该项目建立在主要研究人员的研究和培训经验的基础上，他们与神经科学和计算生物学部门，炎症和再生建模中心以及认知神经基础中心进行了持续成功的合作。受训者包括博士后、研究生和本科生。他们将参加各种综合研究和培训活动，包括定期的学员介绍、期刊俱乐部、工作组和研究研讨会、半年度RTG主题日、年度务静会和在线论坛。该项目针对的生物医学应用对社会具有巨大的重要性，正如将炎症纳入NIH 2008年路线图重点领域和NIH神经科学研究蓝图所象征的那样。

This Research Training Group (RTG) will focus on training a new generation of scientists in (i) the development of analytical and computational algorithms for solving complex spatio-temporal problems that arise in biology and (ii) applications of these and other methods to problems arising in neuroscience and inflammation. In particular, on the computational side, this project will develop effective discretizations of coupled biological processes, iterative solvers and coupling/decoupling strategies. Within the neuroscience application, the investigators will derive new results on propagating waves and sustained activity patterns, synchrony and rhythmicity, noise and synaptic plasticity. Within the inflammation application, the research projects deal with the immune response to influenza infection, inflammation and sepsis, and models of necrotizing enterocolitis and wound healing.This project builds on the research and training experience of the principal investigators who have ongoing successful collaborations with the departments of Neuroscience and of Computational Biology, the Center for Inflammation and Regeneration Modeling and the Center for the Neural Basis of Cognition. The trainees are postdoctoral fellows and graduate and undergraduate students. They will participate in a variety of integrated research and training activities, including regular trainee presentations, journal clubs, working groups and research seminars, semiannual RTG Theme Days, an annual retreat, and an online forum. The biomedical applications targeted in this project are of enormous importance to society, as symbolized by the inclusion of inflammation as an NIH roadmap emphasis area for 2008 and the NIH Blueprint for Neuroscience Research.