MRI: Acquisition of a 400 MHz NMR Spectrometer to Enhance Faculty and Undergraduate Research and Chemical Education at the University of West Georgia

通过这项来自主要研究仪器项目（MRI）的奖励，来自西乔治亚大学的Megumi Fujita和同事Victoria Geisler、Partha Ray和Spencer Slattery将获得一台400 MHz核磁共振（NMR）光谱仪，该光谱仪带有逆探头、自动调谐单元、低温控制杜瓦瓶、抗振动系统和样品转换器。所要求的仪器将允许在有机/无机领域进行研究，并且还将通过允许调查顺磁性样品、广泛的核、可变温度操作和水样的水抑制来提供增强的能力。该仪器将直接影响的特定研究领域包括：(i)开发用于环境无害氧化的过渡金属催化剂，（ii）设计具有可调谐金属-金属偶联的配体桥接双金属和三金属分子开关，（iii）合成基于嘧啶二氮嘧啶的叶酸作为潜在的抗肿瘤药物，以及（iv）通过合成鞘氨醇类似物抑制蛋白激酶C的错误信号传导。核磁共振波谱学是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机/无机化学、生物化学和环境产生影响。

With this award from the Major Research Instrumentation program (MRI), Megumi Fujita and colleagues Victoria Geisler, Partha Ray, and Spencer Slattery from the University of West Georgia will acquire a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer with an inverse probe, auto-tuning unit, Dewar for low-temperature control, anti-vibration system and sample changer. The requested instrument will allow research in organic/inorganic areas and will also provide enhanced capacity by allowing investigation of paramagnetic samples, a wide range of nuclei, variable temperature operations, and water suppression of aqueous samples. Specific areas of research that will be directly impacted by the instrument include: (i) development of transition metal catalysts for environmentally benign oxidation, (ii) the design of ligand-bridged bi- and tri-metallic molecular switches with tunable metal-metal coupling, (iii) the synthesis of pyrimidodiazipine-based folates as potential anti-tumor agents, and (iv) inhibition of faulty signaling by Protein Kinase C via synthesis of sphingosine analogues. Nuclear Magnetic Resonance spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry, biochemistry and the environment.