Acquisition of a Cyber-Enabled 600 MHz NMR Spectrometer for Research and Teaching

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。在化学研究仪器和设施：多用户计划（CRIF:MU）的支持下，韦恩州立大学化学系将获得一台网络支持的600 MHz核磁共振（NMR）光谱仪。它将被用于跨越许多化学领域的研究项目，包括(a)磁共振成像（MRI）和不对称催化的化学；(b)利用两性离子多糖（zps）研制合成碳水化合物疫苗；(c)发展新的通用方法，方便地构造六元环和中型环系统（碳环和杂环）；(d)应用于各种生物活性、结构具有挑战性的天然产物的全合成；(e)开发合成复合低聚糖和糖缀合物的新策略；(f)具有药理活性的天然产物的总合成。多核磁共振波谱是合成化学中必不可少的分析工具。核磁共振光谱使研究人员能够识别他们的反应产物，包括意想不到的物质和杂质。它们通过检测原子的核自旋特性引起的能级之间的转换，揭示了分子和材料中原子之间连通性的信息——即它们的结构。该仪器将对华盛顿州立大学的教育和培训任务产生重要和广泛的影响。它将用于支持本科生、研究生和博士后研究人员的研究项目，包括传统上代表性不足的群体（约占华盛顿州立大学入学人数的25%）以及附近较小的学院和大学。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With support from the Chemistry Research Instrumentation and Facilities:Multiuser program (CRIF:MU), the Department of Chemistry at Wayne State University (WSU) will acquire a cyber-enabled 600 MHz nuclear magnetic resonance (NMR) spectrometer. It will be employed in research projects that span many areas of chemistry including (a) the chemistry of magnetic resonance imaging (MRI) and asymmetric catalysis; (b) the development of synthetic carbohydrate-based vaccines using zwitterionic polysaccharides (ZPSs); (c) the development of new, general methods for facile construction of six-membered and medium-sized ring systems (carbocycles and heterocycles); (d) applications to total synthesis of a wide variety of biologically active, structurally challenging natural products; (e) the development of new strategies for the synthesis of complex oligosaccharides and glycoconjugates; and (f) total synthesis of pharmacologically active natural products.Multinuclear NMR spectroscopy is an essential analytical tool in synthetic chemistry. NMR spectra enable researchers to identify their reaction products including unexpected substances and impurities. They reveal information on the connectivity of the atoms in molecules and materials - i.e. their structures - by detecting transitions between energy levels arising from the nuclear spin properties of atoms. The instrument will have an important and broad-based impact on WSU education and training mission. It will be used to support research projects of undergraduates, graduate students, and postdoctoral researchers, including traditionally underrepresented groups (that make up ca. 25% of the enrollment at WSU) as well at smaller nearby colleges and universities.