Natural Products Synthesis via Organoiron Methodology

本项目将继续致力于开发新的有机金属方法，以立体选择的方式制备C-C键，并研究该方法的应用。特别是（2-烯基-3-戊烯-1,5-二基）铁配合物的制备及其转化为乙烯基环丙烷和二乙烯基环丙烷。二乙烯基环丙烷很可能重排成环庚二烯。这些反应将应用于β -氨基环丙烷羧酸和frondosin A的合成，frondosin A是白细胞介素-8与其受体结合的抑制剂。通过这个奖项，有机和大分子化学项目支持了马凯特大学化学系威廉·a·唐纳森教授的研究。Donaldson教授的研究工作围绕有机金属方法的发展，以形成环丙烷和环庚二烯，这些结构基序存在于各种生物相关分子中。该方法的成功发展将对制药和农业工业的合成产生影响。

This project will continue work to develop new organometallic methodology to prepare C-C bonds in a stereoselective fashion, and applications of this methodology. In particular, the preparation of (2-alkenyl-3-pentene-1,5-diyl)iron complexes and their transformation into vinylcyclopropanes and divinylcyclopropanes will be targeted. The divinylcyclopropanes are likely to undergo rearrangement to cycloheptadienes. These reactions will be applied to the synthesis of beta-aminocyclopropanecarboxylic acids and frondosin A, an inhibitor of the binding of interleukin-8 to its receptor.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor William A. Donaldson of the Department of Chemistry at Marquette University. Professor Donaldson's research efforts revolve around the development of organometallic methodology for the formation of cyclopropanes and cycloheptadienes, structural motifs present in a variety of biologically relevant molecules. Successful development of the methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.