U.S.-Japan Planning Visit: Hormonal control of body fluid homeostasis in fish; Interactions between fast-acting and slow-acting hormones

Oise-0852518(Grau，夏威夷大学)？鱼类体液平衡的激素控制：快效荷尔蒙和慢效荷尔蒙之间的相互作用？摘要该奖项支持PiGrau和东京大学的Yoshio Takei教授计划和早期合作研究活动，以进一步开展对两种泛盐生硬骨鱼：鳗鱼和罗非鱼的比较研究，以阐明面对环境盐度的巨大变化时渗透调节和离子调节所采用的共同机制。这些鱼是比较研究的理想模型，因为它们与高等脊椎动物(包括人类)有许多共同特征，这些脊椎动物参与体液的动态平衡。参与鱼类渗透调节适应的激素可以分为两类：快速作用的激素和缓慢但长效的激素。这两类激素之间的相互作用还不是很清楚。该建议的目标是1)整合通常截然不同和相互独立的科学研究领域，即快速作用荷尔蒙和长效荷尔蒙，以及鳗鱼和罗非鱼；2)启动合作研究，以确定调节鳗鱼和罗非鱼相关内分泌系统活动的关键基因和蛋白质，以应对盐度的环境变化；3)开发新的方法、概念和方法，使年轻科学家接触到单一实验室无法提供的独特的知识和培训组合，以及4)培养超越拟议工作的个人和专业关系。双方青年科学家、博士后研究员、研究生和教职员工将参加小型研讨会和研讨会，并在武井？S博士实验室进行短期培训。

OISE-0852518 (Grau, University of Hawaii) ?Hormonal control of body fluid homeostasis in fish: Interactions between fast-acting hormones and slow-acting hormones?Abstract This award supports planning and early-stage collaborative research activities between PI Grau and Professor Yoshio Takei of the University of Tokyo to further develop comparative studies on two euryhaline teleosts, eel and tilapia, to elucidate shared mechanisms that are employed in osmotic and ionic regulation in the face of large changes in environmental salinity. These fishes are ideal models for comparative studies, since they share many features in common with higher vertebrates including humans that are involved in homeostasis of body fluids. Hormones involved in osmoregulatory adaptation in fish can be classified into two categories; fast-acting hormones and slow- but long-acting hormones. Interactions between the two categories of the hormones are not well understood. The goals of the proposal are to 1) integrate areas of scientific inquiry that are typically distinct and separate from one another, i.e., fast-acting hormones vs. long-lasting hormones, and eel vs. tilapia; 2) initiate collaborative research to identify key genes and proteins that regulate activities of relevant endocrine systems in both eel and tilapia in response to environmental changes in salinity; 3) develop new methods, concepts and approaches by exposing young scientists to a unique mixture of knowledge and training not available in a single laboratory, and 4) foster personal and professional relationships that will extend beyond the proposed work. Young scientists, postdoctoral fellows and graduate students, and faculty on both sides will participate in minisymposia and workshops as well as have short-term training experiences in Dr. Takei?s lab.