Fulvene Catalysis: Development of a New Platform for Asymmetric Catalysis

这项拟议的研究涉及有机分子催化活化的新概念的发展。基于可逆富烯形成这一史无前例的想法，这项工作有望促进一系列迄今未知的合成转化的发展，并为手性对映体分子的合成提供一种非常通用但简单的新范式。通过这一奖项，有机和高分子化学计划支持哥伦比亚大学化学系特里斯坦·兰伯特教授的研究。兰伯特教授的研究涉及对反应催化中的新概念的研究。这些努力提供了开辟反应设计新领域和开发更快速、经济和环境友好的化学工艺的潜力。这项拟议研究的成功开展将对制药、农业和材料工业的合成产生广泛影响。

The proposed research concerns the development of a new concept for the catalytic activation of organic molecules. Based on the unprecedented idea of reversible fulvene formation, this work promises to facilitate the development of a broad range of heretofore unknown synthetic transformations and to provide an exceptionally versatile yet simple new paradigm for the synthesis of enantiopure chiral molecules.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Tristan Lambert of the Department of Chemistry at Columbia University. Professor Lambert's research involves the investigation of new concepts in reaction catalysis. These efforts offer the potential to open new areas of reaction design and to develop more rapid, economic, and environmentally benign chemical processes. Successful development of the proposed research will have widespread impact on synthesis in the pharmaceutical, agricultural, and materials-based industries.