Cold Spring Harbor Laboratory Advanced Bacterial Genetics Course

在这个项目中，冷泉港实验室将继续其非常成功的高级细菌遗传学研究生实验室短期课程。这个密集和大量超额申请课程有着悠久的血统尖端先进的培训,现代微生物遗传学,其根源在实验室课程于1945年开始由诺贝尔奖得主马克斯·德尔布吕克。为期三周的暑期课程为每个参与者准备直接进入研究，利用细菌系统分子遗传学的先进技术和概念。由于课程实验处理真实的研究问题，除了让学生接触不同的技术，他们还提供实验设计，故障排除和真实数据分析方面的培训。每天的讨论时间涵盖方法论、实验设计和分析，并邀请演讲者向学生介绍现代微生物研究的各个领域。本课程鼓励具有不同背景和兴趣的新研究者之间的互动，并为现代微生物学的研究提供培训。更广泛的影响培养科学家在细菌遗传学的最新技术对于我们更好地了解许多生命系统是很重要的，因为细菌在我们的环境中无处不在，对人类生活至关重要，有时在传染病、环境失衡甚至生物恐怖主义方面代表着重大或潜在的威胁。每年，这门课程都会培养新一代的年轻科学家，用最先进的技术来探索细菌的内部工作原理，以及如何将这种理解应用于生物技术和农业的各种应用。考虑到与多细胞生物相比，细菌细胞相对简单，科学家们现在正试图用遗传学和计算机建模相结合的方法来模拟整个细胞系统，以了解这些生物的基本运作系统。该课程为学生和教师提供了肥沃的土壤，让他们在轻松而密集的环境中会面并讨论科学的复杂性，许多人随后将其视为他们科学生涯中最重要和最具形成性的一些，使合作和互动得以维持和加强，并持续数年。

In this project, Cold Spring Harbor Laboratory will continue its highly successful postgraduate laboratory short course in Advanced Bacterial Genetics. This intensive and heavily over-subscribed course has a long pedigree of advanced training in cutting-edge, modern microbial genetics, with its roots in a laboratory course started by Nobel laureate Max Delbruck in 1945. The three-week summer course prepares each participant to enter directly into research that makes use of advanced techniques and concepts in the molecular genetics of bacterial systems. Because the course experiments address real research questions, in addition to exposing students to different techniques, they provide training in experimental design, trouble-shooting and real data analysis. Daily discussion periods cover the methodology, experimental design and analysis and invited speakers introduce students to diverse areas of modern microbial research. The course stimulates interaction among new investigators with diverse backgrounds and interest and provides training towards research in modern microbiology.Broader ImpactTraining scientists in the latest techniques in bacterial genetics is important for our greater understanding of many living systems, since bacteria are omnipresent in our environment and essential to human life, at times representing significant or potential threats in terms of infectious diseases, environmental imbalance and even bioterrorism. Each year, this course trains a new generation of young scientists in state-of-the-art techniques in how to probe the inner workings of bacteria, and how to use this understanding in a variety of applications in biotechnology and agriculture. Given the relative simplicity of the bacterial cell compared to that of multicellular organisms, scientists are now attempting to model the entire system of the cell, using a combination of genetics and computer modeling to understand the fundamental operation system of these organisms. The course provides fertile ground for students and faculty to meet and discuss the intricacies of the science in a relaxed but intensive environment, which many subsequently cite as some of the most significant and formative of their scientific careers, enabling collaboration and interactions that are maintained and strengthened for years into the future.