MRI: Acquisition of a 400 MHz NMR Spectrometer to Support Undergraduate Research and Chemical Education at Towson University

该奖项是根据2009年《美国复苏和再投资法案》(Public Law 111-5)获得的。在重大研究仪器(MRI)项目的这一奖项下，首席研究员克莱尔·穆霍罗(Clare Muhoro)和列夫·雷日科夫(Lev Ryzhkov)以及来自道森大学(Towson University)的同事蒂莫西·布伦克(Timothy Brunker)、巴里·马古利斯(Barry Marulies)、安娜·玛丽亚·索托(Ana Maria Soto)和香农·斯蒂泽尔(Shannon Stitzel)将获得一台400 MHz核磁共振波谱仪，以支持他们机构的研究和教学。他们的研究横跨化学和生物学领域，包括：1)基于螺吡喃的分子印迹聚合物传感器的研究；2)氨基糖苷类抗生素与RNA结合的研究；3)同位素标记的阿昔洛韦及其代谢物的合成、检测和定量；4)N-甲基氨基甲酸酯农药在水溶液中的降解研究；5)用CIDNP光谱研究伯酰氧基自由基的寿命；6)基于配位络合物的手性分子开关的合成；6)磷酰基(有机)硼烷的合成、表征和应用。该仪器还将用于本科生和研究生(MS)的课程工作的教学和培训，以及Towson的研究。光谱仪将在为马里兰州的技术和科学劳动力培养不同的学生群体方面发挥关键作用。核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机/无机化学和生物化学以及对不同学生群体的培训产生影响。

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).With this award from the Major Research Instrumentation (MRI) program, Principal Investigators Clare Muhoro and Lev Ryzhkov and colleagues Timothy Brunker, Barry Margulies, Ana Maria Soto and Shannon Stitzel from Towson University will acquire a 400 MHz NMR spectrometer to support research and teaching at their institution. Their proposed research spans a number of areas in chemistry and biology, including: 1) the investigation of spiropyran-based molecularly imprinted polymer sensors; 2) the study of the binding of aminoglycoside antibiotics to RNA; 3) the synthesis, detection and quantitation of isotope-labeled acyclovair and its metabolites; 4) the study of the degradation of N-methylcarbamate pesticides under aquatic conditions; 5) the study of the lifetime of primary acyloxy radicals using CIDNP spectroscopy ; 6) the synthesis of coordination complex-based chiral molecular switches and 6) the synthesis, characterization and application of phosphanyl(organyl)boranes. The instrumentation will also be used in teaching and training of undergraduate and graduate students (MS) in coursework, as well as research at Towson. The spectrometer will play a critical role in preparing a diverse group of students for Maryland's technical and scientific workforce. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic/inorganic chemistry and biochemistry, as well as in the training of a diverse group of students.