International Collaboration in Chemistry: Polymer Supported Lanthanide-BINOLate-Based Catalysts

在这个由国际科学与工程办公室和化学部化学催化计划资助的国际化学合作（ICC）项目中，宾夕法尼亚大学的帕特里克J.沃尔什和埃里克J.加泰罗尼亚化学研究所（ICIQ）的Pericàs将把对映选择性镧系元素催化剂与固体载体连接起来，使其易于处理和回收。 杂镧系元素（BINOlate）配合物将通过含二胺的聚合物与固体载体连接，所述聚合物将紧密结合其锂离子，从而产生固态催化剂，所述固态催化剂可以以与其母体化合物相同或更好的性能用于不对称反应。 负载型催化剂也将在间歇和流动反应器中进行研究。 研究生和博士后研究人员将参加沃尔什和Schelter实验室（美国）之间的交流。和Pericàs集团（西班牙）。 这些学生将学习目前在其家乡机构无法获得的新技术。如果成功，这项工作预计将在有机化学，高分子化学，工业和医药合成中产生深远的影响。这种新的设计方法可能会导致新的固体催化剂，能够进行关键的对映选择性转化，然后很容易从反应产物中分离（回收），并在多种应用中重复使用。 流系统的开发是特别有吸引力的，因为它提供了证据，在实现实用的，用户准备好的系统组装团队的增值性质。MICINN将为西班牙调查人员提供支持资金，而NSF将支持美国团队的努力。

In this International Collaboration in Chemistry (ICC) project funded by the Office of International Science and Engineering and the Chemical Catalysis Program of the Chemistry Division, Patrick J. Walsh and Eric J. Schelter, University of Pennsylvania, and Miquel A. Pericàs, Institute of Chemical Research of Catalonia (ICIQ), will link enantioselective lanthanide-based catalysts to solid supports, and enable their facile handling and recycling. Heterobimetallic lanthanide(BINOlate) complexes will be tethered to solid supports through diamine-containing polymers that will tightly bind to their lithium ions, resulting in solid state catalysts which can be used in asymmetric reactions with equal or better performance than their parent compounds. The supported catalysts will also be investigated in batch and flow reactors. Graduate and postdoctoral researchers will participate in exchanges between the Walsh and Schelter labs (U.S.) and the Pericàs group (Spain). These students will learn new techniques that are currently unavailable in their home institutions. If successful, this work is expected to have far reaching implications in organic chemistry, polymer chemistry, and industrial and medicinal synthesis. This novel approach to design may lead to new solid catalysts that are able to perform key enantioselective transformations and then be easily separated from the reaction products (recovered) and reused in multiple applications. The development of flow systems is especially attractive as it provides evidence for the value-added nature of the assembled team in achieving practical, user-ready systems. The MICINN will provide support funds for the Spanish investigators while the NSF will support the U.S. team's efforts.