RUI: Use of Functionalized Dendrimers in Cascade Catalysis

美国国家科学基金会化学部的化学催化项目支持圣本笃学院的Thomas Jones教授合成、表征和评价多功能树突级联催化剂。本工作的目标是将金属和有机金属催化剂附着在G4聚胺基树状大分子的周长上，并对催化剂的优化进行后续的动力学和机理研究。级联催化剂是有机化学中一锅多步反应的重要组成部分。该研究的广泛影响是基于“原子经济”反应的总体发展，这对于减少化学工业中的废物流至关重要，并且可以节省劳动密集型药物多步骤合成的时间。Jones教授与蒙大拿州立大学的Cloninger教授合作进行的这项研究是为了训练本科生研究人员进行合成、用各种分析方法表征以及机械和动力学测量。

The Chemical Catalysis Program in the Chemistry Division at the National Science Foundation supports Professor Thomas Jones of the College of Saint Benedict, for the synthesis, characterization and evaluation of multifunctional dendritic cascade catalysts. The goal of this work is to attach both metal and organometallic catalysts to the perimeter of G4 poly(amido amine) dendrimers, and to make subsequent kinetic and mechanistic studies in regard to catalyst optimization. Cascade catalysts are important for the development of multi-step, one-pot reactions in organic chemistry.Broader impacts of the research are based on the general development of "atom economical" reactions, which are critical for the reduction of the waste stream in the chemical industry and can save time during labor intensive pharmaceutical multistep syntheses. The research by Professor Jones, in collaboration with Professor Cloninger at Montana State University, is geared to the training of undergraduate researchers in synthesis, characterization by a variety of analytical methods, and mechanistic and kinetic measurements.