New Approaches for Efficiency in Synthetic Organic Chemistry

斯坦福大学化学系的Barry M. Trost教授在化学系化学合成项目的资助下，旨在通过不对称催化的发展来提高有机合成的效率。具体来说，有三个催化领域是有针对性的。第一个涉及合理设计配体，以形成双核和异双核金属配合物作为加成反应的催化剂。第二个领域涉及不对称三甲基乙烷环加成。第三部分研究钯催化的不对称烯丙基和苯基烷基化反应。不对称合成的新型Ru-Pd序列反应以及在Mo催化反应背景下对此类系统的检查也将继续进行。从生物学到材料科学的各种应用都需要越来越复杂的有机分子，这就需要提高有机合成的效率。本项目旨在通过高反应选择性和高原子经济性来实现高合成效率。该项目的成功完成将对制药、农化和特种化工行业产生积极影响，并为社会的可持续发展做出积极贡献。该项目还将为研究生和博士后提供优秀的培训，包括那些目前在化学领域代表性不足的人。

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Barry M. Trost of the Department of Chemistry at Stanford University aims to improve efficiency in organic synthesis through the development of asymmetric catalysis. Specifically, three areas of catalysis are targeted. The first involves the rational design of ligands for formation of dinuclear and heterodinuclear metal complexes as catalysts for addition reactions. The second area involves asymmetric trimethylenemethane cycloadditions. The third area examines Pd catalyzed asymmetric allylic and benzylic alkylation. Novel Ru-Pd sequential reactions for asymmetric synthesis and examination of such systems in the context of Mo catalyzed reactions will also be pursued. The need of increasingly complex organic molecules for a myriad of applications ranging from biology to material science heightens the need for increased efficiency in organic synthesis. This project intends to achieve high synthetic efficiency through high reaction selectivity and high atom economy. Successful accomplishment of this project will positively impact the pharmaceutical, agrochemical and specialty chemical industries and contribute positively to the sustainability of the society. The project will also provide excellent trainings to the graduate students and postdoctoral fellows involved, including those currently underrepresented in Chemistry.