CAREER: New Reagents and Strategies for Catalytic Nucleophilic Fluorination

有了这个职业奖，化学合成计划是支持教授阿比盖尔G。Doyle教授发明了亲核取代的新试剂和新策略。本研究的第一个目的是发展以苯甲酰氟为潜在氟源的刘易斯碱催化氢氟化反应。第二个目标是设计区域和立体选择性合成烯丙基和苄基氟的催化方法。该研究有望通过使用廉价且易于获得的氟化物来源制备新型氟化结构单元来促进药剂、农用化学品和功能材料的发现和制造。通过这些调查积累的知识应该让位于更好地了解脂肪族氟取代在生物医学和基础研究中的影响，并为反应设计提供新的机会。多伊尔教授还将启动教育推广项目，交织研究和教学。教育计划的影响将是扩大对STEM领域的参与，特别是代表性不足的少数民族和妇女，通过这些学生早期参与实践研究活动。其中一个项目涉及为特伦顿地区社区学院的学生提供服务，该学院为多样化的人口提供服务，包括代表性不足的少数民族和低收入学生，有机会在多伊尔教授的实验室进行研究，作为他们荣誉化学课程的一部分。其次，普林斯顿大学的学生邀请系列讲座将扩大到包括来自行业（主要是本科院校）和政府机构的演讲者，让学生接触到STEM学科更多样化的职业机会。

With this CAREER Award, the Chemical Synthesis Program is supporting the research of Professor Abigail G. Doyle of Princeton University to invent new reagents and strategies for nucleophilic fluorination. The first objective of this research is to develop Lewis base-catalyzed hydrofluorinations using benzoyl fluoride as a latent fluoride source. The second objective is to design catalytic methods for the regio- and stereoselective synthesis of allylic and benzylic fluorides. The research is expected to facilitate the discovery and manufacture of pharmaceutical agents, agrochemicals, and functional materials by enabling the preparation of novel fluorinated building blocks using inexpensive and readily available fluoride sources. Knowledge accrued through these investigations should give way to a better understanding of the impact of aliphatic fluorine substitution in biomedical and basic research and afford new opportunities for reaction design. Professor Doyle will also be initiating educational outreach projects that interweave research and teaching. The impact of the education plan will be to broaden participation in STEM fields, particularly by underrepresented minorities and women, through early engagement of these students in hands-on research activities. One program involves providing students from a Trenton-area community college that serves a diverse population, including underrepresented minorities and low-income students, the opportunity to pursue research as part of their honors chemistry curriculum in Professor Doyle's laboratory. Second, the student invited lecture series at Princeton will be expanded to include speakers from industry, primarily undergraduate institutions, and government agencies to expose students to more varied career opportunities in the STEM disciplines.