Polycomponent Catalysis in Organic Synthesis

在这个由化学合成（SYN）计划资助的项目中，约翰霍普金斯大学的Thomas Lectka教授开发了新的化学方法，该方法使用几种独立的催化剂协同工作，以生产化学上有趣且有用的产品，这些产品不易通过其他方式获得。除了理论兴趣外，操作简单、催化剂负荷低、相互相容性和范围广也是基本目标。该方法的基础将是多组分催化（例如，与有机金属配合物、路易斯酸和/或相转移催化剂结合的催化亲核试剂），从而产生合成药学上相关功能化目标的有力方法，包括手性氟化物、生物碱、内酰胺和相关化合物。特别注意到对氟化新方法的关注；氟化有机分子为药物发现提供了富有成果和令人兴奋的新线索。该项目将服务于三个主要目标：1)开发复杂但非常有价值的新化学工艺；2)合成药学相关靶点和其他有用分子的新方法；3)为研究生（包括代表性不足群体的成员）提供合成化学的实践培训。同样，让许多本科生参与综合项目（特别是在以医院为导向的约翰霍普金斯大学）将有助于他们为从事与健康相关的职业做好准备。

In this project funded by the Chemical Synthesis (SYN) Program, Prof. Thomas Lectka of Johns Hopkins University develops new chemical methods that employ several independent catalysts working synergistically to produce chemically interesting and useful products not easily accessible in other ways. Besides theoretical interest, operational simplicity, low catalyst loadings, mutual compatibility, and broad scope will be fundamental goals as well. The foundation of the approach will be polycomponent catalysis (for example, a catalytic nucleophile in combination with an organometallic complex, a Lewis acid, and/or a phase transfer catalyst) that results in powerful methods for the synthesis of pharmaceutically relevant functionalized targets, including chiral fluorides, alkaloids, lactams and related compounds. A focus on new methods of fluorination is especially noted; fluorinated organic molecules provide fruitful and exciting new leads for drug discovery.This project would serve three main goals: 1) the development of complex yet highly worthwhile new chemical processes; 2) fundamentally new approaches to the synthesis of pharmaceutically relevant targets and other useful molecules; 3) and practical training in synthetic chemistry for graduate students (including members of underrepresented groups). Equally, exposure of numerous undergraduates to synthetic projects (especially at hospital-oriented Johns Hopkins) will help to prepare them for careers in health-related occupations.